Trial reportBritish journal of pharmacology2001
Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men.
Trial report in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 85 citations in OpenAlex.
- Thermotherapy reduces blood pressure and circulating endothelin-1 concentration and enhances leg blood flow in patients with symptomatic peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men.The Journal of physiology · 2013Trial
- Trial
- Vasodilator effects of the endothelin ET receptor selective antagonist BMS-193884 in healthy men.British journal of clinical pharmacology · 2005Trial
- Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure.Heart (British Cardiac Society) · 2005Trial
- Unveiling orthostatic hypotension in precapillary pulmonary hypertension.ERJ open research · 2026Article
- Gut microbiota and atrial cardiomyopathy.Frontiers in cardiovascular medicine · 2025Review
- Smoking cessation reduces systemic inflammation and circulating endothelin-1.Scientific reports · 2021Article
- Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- The role of endothelin A receptors in peripheral vascular control at rest and during exercise in patients with hypertension.The Journal of physiology · 2020Article
- Measurement of plasma endothelin-1 concentration in healthy horses and horses with cardiac disease during rest and after exercise.The Journal of veterinary medical science · 2019Article
- Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone.Frontiers in pharmacology · 2017Article
- Endothelin.Pharmacological reviews · 2016Review
- Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development.Life sciences · 2014Article
- Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.PloS one · 2014Article
- Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease.Biochemical pharmacology · 2012Review
- Enhanced endothelin-1 system activity with overweight and obesity.American journal of physiology. Heart and circulatory physiology · 2011Article
- Role of the endothelin axis and its antagonists in the treatment of cancer.British journal of pharmacology · 2011Review
- The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice.Diabetologia · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effect on systemic haemodynamics of BQ-123, a selective endothelin A (ETA) receptor antagonist, was investigated in healthy men by giving, on separate occasions, ascending intravenous doses of 100, 300, 1000 and 3000 nmol min(-1) BQ-123, each for 15 min, in a randomized, placebo-controlled, double-blind study. The response of forearm blood flow to brachial artery infusion of endothelin-1 (ET-1; 5 pmol min(-1) for 90 min) was also studied using bilateral forearm plethysmography, after systemic pre-treatment, on separate occasions, with one of two doses of BQ-123 (300 and 1000 nmol min(-1) for 15 min) or placebo. 2. Systemic BQ-123 dose-dependently decreased systemic vascular resistance (P<0.01 for all doses vs placebo) and mean arterial pressure (P<0.05 for 300 nmol min(-1) and P<0.01 for 1000 and 3000 nmol min(-1)) during the 60 min following infusion. There were concurrent increases in heart rate and cardiac index. BQ-123, when infused systemically for 15 min, appeared to reach a maximum effect at 1000 nmol min(-1). 3. Intra-brachial ET-1 infusion, after pre-treatment with placebo, caused a slow onset progressive forearm vasoconstriction without systemic effects. This vasoconstriction was attenuated by pre-treatment with BQ-123 at 300 nmol min(-1) and abolished by BQ-123 at 1000 nmol min(-1) (P<0.01 vs placebo). 4. These effects occurred at concentrations of BQ-123 in the plasma (510+/-64 nmol l(-1)) that were ETA receptor selective, and were not accompanied by an increase in plasma ET-1 that would have indicated ETB receptor blockade. 5. We conclude that ETA-mediated vascular tone contributes to the maintenance of basal systemic vascular resistance and blood pressure in healthy men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.