ArticleLeukemia2001
Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues.
Article in Leukemia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Cancer incidence rates and trends among children and adolescents in Piedmont, 1967-2011.PloS one · 2017Article
- International long-term trends and recent patterns in the incidence of leukemias and lymphomas among children and adolescents ages 0-19 years.International journal of cancer · 2016Article
- A web tool for age-period-cohort analysis of cancer incidence and mortality rates.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Article
- Are incidence rates of adult leukemia in the United States significantly associated with birth cohort?Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Effects of changes in diagnosis and registration on time trends in recorded childhood cancer incidence in Great Britain.British journal of cancer · 2012Article
- Perinatal and family risk factors for non-Hodgkin lymphoma in early life: a Swedish national cohort study.Journal of the National Cancer Institute · 2012Article
- Age-period-cohort models in cancer surveillance research: ready for prime time?Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Article
- Age-period-cohort modelling of non-Hodgkin's lymphoma incidence in a French region: a period effect compatible with an environmental exposure.Environmental health : a global access science source · 2010Article
- Proportional hazards models and age-period-cohort analysis of cancer rates.Statistics in medicine · 2010Article
- Incidence of cancer in children residing in ten jurisdictions of the Mexican Republic: importance of the Cancer registry (a population-based study).BMC cancer · 2007Article
- Classification and incidence of cancers in adolescents and young adults in England 1979-1997.British journal of cancer · 2002Article
- Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years.Leukemia · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The age-sex distributions and temporal trends in incidence of leukaemia and lymphoma from the Manchester Children's Tumour Registry (MCTR), 1954-1998, are reported. This 45-year study includes 1795 children, all of whom had a histologically and/or cytologically verified leukaemia or lymphoma. At the time of their diagnoses all the children were under 15 years of age and were resident in a geographically defined area of northwest England covered by the MCTR. Log-linear modelling identified significant linear increases in acute lymphoblastic leukaemia (ALL) (average annual increase 0.7%; P= 0.005) and in Hodgkin's disease (HD) (1.2%, P=0.04), but not in acute myeloid leukaemia (AML), nor in non-Hodgkin's lymphoma (NHL). The increase in ALL was most pronounced amongst males, aged 1-4 years, and is likely to be due to precursor B-cell leukaemias. The increases in ALL and HD are discussed in relation to current hypotheses suggesting a role for infection. Additionally, a non-linear cohort effect was identified for NHL (P= 0.008), which may indicate the involvement of environmental factors other than infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.