ReviewClinical microbiology reviews2001
Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment.
Review in Clinical microbiology reviews, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 170 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation the Relationship Between Periodontal Disease and 'Asprosin, Adropin, Irisin' Levels
Treatment of Periodontal and Peri-Implant Pockets With a Novel Collagen Hydrogel: A Multicenter Retrospective Study on the Clinical Use of the H42 Medical Device
Who cites it
170 citing papers in PubMed, 1 synthesis or guideline pooled it, 495 citations in OpenAlex.
- Oral health-related quality of life in patients with periodontitis: a systematic review and meta-analysis.Frontiers in oral health · 2025Pooled it
- Periodontal Disease Diagnosis by a Chemically Etched Single-Mode Fiber-Optic Biosensor for Label-Free Detection of Matrix Metalloproteinase-8 (MMP-8).Biosensors · 2026Article
- Article
- Treatment preferences related to pulpectomy and prosthetic restorations among Lithuanian general dentists and prosthodontists.Acta odontologica Scandinavica · 2026Article
- Nisin bacteriocin blocks T. denticola-triggered MMP2 activation and pathogen internalization via TLR2.Scientific reports · 2026Article
- Effect of periodontal disease on bite force and the temporomandibular joint disorders: a cross-sectional study.BMC oral health · 2026Article
- Review
- Review
- Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Is there a relationship between periodontal conditions and asprosin levels in gingival crevicular fluid, saliva and serum?BMC oral health · 2025Observational
- Age-Related Oral and Para-Oral Tissue Disorders: The Evolving Therapeutic and Diagnostic Potential of Exosomes.Dentistry journal · 2025Review
- The extracellular vesicle-based treatment: a developing strategy for periodontal diseases.Frontiers in immunology · 2025Review
- Article
- The Effect of Carica Papaya on Periodontal Disease: A Systematic Review and Meta-Analysis.Advanced biomedical research · 2025Review
- Correlation Between Periodontal Disease and Oral, Oropharyngeal, and Parapharyngeal Cancers.Clinical, cosmetic and investigational dentistry · 2025Article
- Chemical characterization and antimicrobial activities of Citrus aurantifolia peel oils and Ocimum sanctum ethanolic extract.PloS one · 2025Article
- Effect of scaling and root planing on root canal-treated teeth with periodontal pockets.Bioinformation · 2025Article
- Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment-The Role of Ceragenins in the Development of New Therapeutic Methods.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Effects of Oleanolic Acid Derived from Wine Pomace on Periodontopathic Bacterial Growth in Healthy Individuals: A Randomized Placebo-Controlled Study.Dentistry journal · 2024Article
- The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases.Biomedicines · 2024Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Periodontal disease is perhaps the most common chronic infection in adults. Evidence has been accumulating for the past 30 years which indicates that almost all forms of periodontal disease are chronic but specific bacterial infections due to the overgrowth in the dental plaque of a finite number of mostly anaerobic species such as Porphyromonas gingivalis, Bacteroides forsythus, and Treponema denticola. The success of traditional debridement procedures and/or antimicrobial agents in improving periodontal health can be associated with the reduction in levels of these anaerobes in the dental plaque. These findings suggest that patients and clinicians have a choice in the treatment of this overgrowth, either a debridement and surgery approach or a debridement and antimicrobial treatment approach. However, the antimicrobial approach, while supported by a wealth of scientific evidence, goes contrary to centuries of dental teaching that states that periodontal disease results from a "dirty mouth." If periodontal disease is demonstrated to be a risk factor for cardiovascular disease and stroke, it will be a modifiable risk factor since periodontal disease can be prevented and treated. Since the antimicrobial approach may be as effective as a surgical approach in the restoration and maintenance of a periodontally healthy dentition, this would give a cardiac or stroke patient and his or her physician a choice in the implementation of treatment seeking to improve the patient's periodontal condition so as to reduce and/or delay future cardiovascular events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.