ArticleThe American journal of pathology2001
Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Permission to pass: on the role of p53 as a gatekeeper for aneuploidy.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Detection of circulating genetically abnormal cells using 4-color fluorescence in situ hybridization for the early detection of lung cancer.Journal of cancer research and clinical oncology · 2021Article
- Circulating Genetically Abnormal Cells Add Non-Invasive Diagnosis Value to Discriminate Lung Cancer in Patients With Pulmonary Nodules ≤10 mm.Frontiers in oncology · 2021Article
- Genomic Instability in Circulating Tumor Cells.Cancers · 2020Review
- Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability.Molecular biology of the cell · 2018Article
- p73 regulates serine biosynthesis in cancer.Oncogene · 2014Article
- Chronic Exposure to Particulate Hexavalent Chromium Alters Cdc20 Protein Localization, Interactions and Expression.Journal of carcinogenesis & mutagenesis · 2013Article
- A clinical overview of centrosome amplification in human cancers.International journal of biological sciences · 2011Review
- Mechanisms of chromosomal instability.Current biology : CB · 2010Review
- TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.Genes & development · 2008Article
- Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer.American journal of respiratory and critical care medicine · 2007Article
- Reduced expression of Dicer associated with poor prognosis in lung cancer patients.Cancer science · 2005Article
- Throwing new light on lung cancer pathogenesis: updates on three recent topics.Cancer science · 2005Review
- Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers.The American journal of pathology · 2003Article
- Chromosomal abnormalities in non-small cell lung carcinomas and in bronchial epithelia of high-risk smokers detected by multi-target interphase fluorescence in situ hybridization.The Journal of molecular diagnostics : JMD · 2003Article
- Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.BMC cell biology · 2002Article
- Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.Oncogene · 2002Review
- Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis.Oncogene · 2002Review
- Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers.Oncogene · 2002Article
- High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas.Journal of neuro-oncologyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Karyotype and fluorescence in situ hybridization analyses have demonstrated the frequent presence of an altered static state of the number of chromosomes (ie, aneuploidy) in lung cancer, but it has not been directly established whether aneuploidy is in fact associated with a persistent increase in the rate of chromosomal losses and gains (ie, chromosome instability, or CIN). The study presented here used a panel of 10 lung cancer cell lines to provide for the first time direct evidence that CIN is a common feature in lung cancer cell lines in association with the presence of significant aneuploidy. In addition, we found that the CIN phenotype correlates well with the presence of p53 mutations. However, human papilloma virus 16-E6-directed inactivation of p53 in a representative non-CIN lung cancer cell line did not result in the induction of CIN, at least up to the 25th generation, suggesting that inactivation of p53 itself is unlikely to directly induce CIN in lung cancer cells. Interestingly, however, significant CIN could be induced in conjunction with the generation of aneuploid populations when the mitotic spindle formation was transiently abrogated in p53-inactivated cells. These results suggest that inactivation of p53 may allow lung cancer cells to go through an inappropriate second division cycle under certain forms of mitotic stresses, which would result in the induction of the CIN phenotype in conjunction with the generation of aneuploidy.
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