ArticleThe American journal of pathology2001
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- An up-date on novel molecular targets in testicular germ cell tumors subtypes.Intractable & rare diseases research · 2019Article
- Testicular cancer from diagnosis to epigenetic factors.Oncotarget · 2017Review
- An up-date on epigenetic and molecular markers in testicular germ cell tumors.Intractable & rare diseases research · 2017Article
- New perspective on molecular markers as promising therapeutic targets in germ cell tumors.Intractable & rare diseases research · 2016Article
- A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster.BMC genetics · 2014Article
- Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe-gastric epithelial cells cross-talk.Medical microbiology and immunology · 2013Review
- STUbLs in chromatin and genome stability.Biopolymers · 2013Review
- Recent advances in the biology of germ cell tumors: implications for the diagnosis and treatment.Journal of endocrinological investigation · 2012Review
- Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach.Physiological genomics · 2010Article
- Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase.Asian journal of andrology · 2010Article
- The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks.Cell cycle (Georgetown, Tex.) · 2009Article
- SUMO-targeted ubiquitin ligases in genome stability.The EMBO journal · 2007Article
- An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention.BMC bioinformatics · 2005Article
- HMGA1 and HMGA2 protein expression in mouse spermatogenesis.Oncogene · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RING-finger protein RNF4 modulates both steroid-receptor-dependent and basal transcription and interacts with a variety of nuclear proteins involved in cell growth control. RNF4 is expressed at very high levels in testis and at much lower levels in several other tissues. We show that in germ cells RNF4 expression is strongly modulated during progression of spermatogonia to spermatids, with a peak in spermatocytes. Analysis of human testicular germ cell tumors shows that RNF4 is not expressed in all tumors analyzed including seminomas, the highly malignant embryonal carcinomas, yolk sac, and mixed germ cell tumors. We also show that the ectopically expressed RNF4 gene inhibits cell proliferation of both somatic and germ cell tumor-derived cells. Mutation of critical cysteine residues in the RING finger domain abolished the RNF4 growth inhibition activity. Our results suggest that the lack of RNF4 expression may play a role in the progression of testicular tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.