ArticleThe Biochemical journal2001
S-phase-specific expression of the Mad3 gene in proliferating and differentiating cells.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Tumor Heterogeneity Induces Pro- and Anti-metastatic Myeloid Cell Phenotypes in Breast Cancer Lung Metastasis.bioRxiv : the preprint server for biology · 2026Article
- Review
- MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis.Cells · 2021Article
- Overexpression of MAX dimerization protein 3 (MXD3) predicts poor prognosis in clear cell renal cell carcinoma.Translational andrology and urology · 2021Article
- MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types.Computational and structural biotechnology journal · 2021Article
- Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma.Frontiers in molecular biosciences · 2019Article
- Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.Biochimica et biophysica acta · 2015Review
- Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells.Blood cells, molecules & diseases · 2015Article
- Focus formation: a cell-based assay to determine the oncogenic potential of a gene.Journal of visualized experiments : JoVE · 2014Article
- MXD3 regulation of DAOY cell proliferation dictated by time course of activation.BMC cell biology · 2014Article
- Article
- Regulation of the MAD1 promoter by G-CSF.Nucleic acids research · 2008Article
- Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT.Journal of virology · 2008Article
- A novel role of the Mad family member Mad3 in cerebellar granule neuron precursor proliferation.Molecular and cellular biology · 2007Article
- PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein.The Biochemical journal · 2004Article
- Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.The Biochemical journal · 2003Article
- The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1.The Biochemical journal · 2003Article
Corrections and comments
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Myc/Max/Mad transcription factor network plays a central role in the control of cellular proliferation, differentiation and apoptosis. In order to elucidate the biological function of Mad3, we have analysed the precise temporal patterns of Mad3 mRNA expression during the cell cycle and differentiation in cultured cells. We show that Mad3 is induced at the G1/S transition in proliferating cells; expression persists throughout S-phase, and then declines as cells pass through G2 and mitosis. The expression pattern of Mad3 is coincident with that of Cdc2 throughout the cell cycle. In contrast, the expression of Mad3 during differentiation of cultured mouse erythroleukemia cells shows two transient peaks of induction. The first of these occurs at the onset of differentiation, and does not correlate with the S-phase of the cell cycle, whereas the second is coincident with the S-phase burst that precedes the terminal stages of differentiation. Our results therefore suggest that Mad3 serves a cell-cycle-related function in both proliferating and differentiating cells, and that it may also have a distinct role at various stages of differentiation.
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