ArticleAmerican journal of human genetics2001
Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of aging on the male reproductive system.Journal of assisted reproduction and genetics · 2016Pooled it
- Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father.Journal of assisted reproduction and genetics · 2025Article
- Genes and Pathways Underpinning Klinefelter Syndrome at Bulk and Single-Cell Levels.Biochemical genetics · 2024Article
- Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children.Reproduction (Cambridge, England) · 2024Review
- Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans.Cellular and molecular life sciences : CMLS · 2024Review
- The Role of Advanced Parental Age in Reproductive Genetics.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Paternal age, risk of congenital anomalies, and birth outcomes: a population-based cohort study.European journal of pediatrics · 2023Article
- A microbiota and dietary metabolite integrates DNA repair and cell death to regulate embryo viability and aneuploidy during aging.Science advances · 2023Article
- Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.Genes · 2023Review
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Satellite DNAs and human sex chromosome variation.Seminars in cell & developmental biology · 2022Review
- Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.The EMBO journal · 2021Article
- USP26: a genetic risk factor for sperm X-Y aneuploidy.The EMBO journal · 2021Article
- Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.Journal of assisted reproduction and genetics · 2019Article
- Article
- Meiotic spindle assembly checkpoint and aneuploidy in males versus females.Cellular and molecular life sciences : CMLS · 2019Review
- Reproductive genetics and the aging male.Journal of assisted reproduction and genetics · 2018Review
- Male biological clock: a critical analysis of advanced paternal age.Fertility and sterility · 2015Review
- Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring.Reproductive biology and endocrinology : RB&E · 2015Review
- The effects of advanced paternal age on fertility.Asian journal of andrology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
With increasing availability of drugs for impotence and advanced reproductive technologies for the treatment of subfertility, more men are fathering children at advanced ages. We conducted a study of the chromosomal content of sperm of healthy men aged 24-57 years to (a) determine whether father's age was associated with increasing frequencies of aneuploid sperm including XY, disomy X, disomy Y, disomy 21, and sperm diploidy, and (b) examine the association between the frequencies of disomy 21 and sex-chromosomal aneuploidies. The study group consisted of 38 fathers of boys with Klinefelter syndrome (47, XXY) recruited nationwide, and sperm aneuploidy was assessed using multicolor X-Y-21 sperm FISH ( approximately 10,000 sperm per donor). Paternal age was significantly correlated with the sex ratio of sperm (Y/X; P=.006) and with the frequency of XY sperm (P=.02), with a clear trend with age by decades (P<.006). Compared with fathers in their 20s (who had an average frequency of 7.5 XY sperm per 10,000), the frequencies of XY sperm were 10% higher among fathers in their 30s, 31% higher among those in their 40s, and 160% higher among those in their 50s (95% CI 69%-300%). However, there was no evidence for age effects on frequencies of sperm carrying nullisomy sex; disomies X, Y, or 21; or meiosis I or II diploidies. The frequencies of disomy 21 sperm were significantly associated with sex-chromosomal aneuploidy (P=.04)-in particular, with disomy X (P=.004), but disomy 21 sperm did not preferentially carry either sex chromosome. These findings suggest that older fathers produce higher frequencies of XY sperm, which may place them at higher risk of fathering boys with Klinefelter syndrome, and that age effects on sperm aneuploidy are chromosome specific.
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