ArticleJournal of virology2001
Human cytomegalovirus protein US2 interferes with the expression of human HFE, a nonclassical class I major histocompatibility complex molecule that regulates iron homeostasis.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Epstein-Barr Virus Infection Is Associated with Elevated Hepcidin Levels.International journal of molecular sciences · 2023Article
- Ferroptosis in viral infection: the unexplored possibility.Acta pharmacologica Sinica · 2022Review
- The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels.Journal of virology · 2022Article
- HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.Autophagy · 2021Article
- Modulation of innate and adaptive immunity by cytomegaloviruses.Nature reviews. Immunology · 2020Review
- Low iron mitigates viral survival: insights from evolution, genetics, and pandemics-a review of current hypothesis.The Egyptian journal of medical human genetics · 2020Review
- Battle between Host Immune Cellular Responses and HCMV Immune Evasion.International journal of molecular sciences · 2019Review
- Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism.Journal of virology · 2018Article
- Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.Molecular immunology · 2015Review
- Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: so many targets—but how many arrows in the quiver?Cellular & molecular immunology · 2015Review
- White spot syndrome virus protein kinase 1 defeats the host cell's iron-withholding defense mechanism by interacting with host ferritin.Journal of virology · 2015Article
- ER Stress and Iron Homeostasis: A New Frontier for the UPR.Biochemistry research international · 2011Article
- The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation.The Journal of experimental medicine · 2010Article
- Immune evasion during foot-and-mouth disease virus infection of swine.Immunological reviews · 2008Review
- Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS.Cell host & microbe · 2008Article
- Viral infection and iron metabolism.Nature reviews. Microbiology · 2008Review
- The unfolded protein response in hereditary haemochromatosis.Journal of cellular and molecular medicine · 2008Review
- Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Manipulation of iron to determine survival: competition between host and pathogen.Immunologic research · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
HFE is a nonclassical class I major histocompatibility complex (MHC) molecule that is mutated in the autosomal recessive iron overload disease hereditary hemochromatosis. There is evidence linking HFE with reduced iron uptake by the transferrin receptor (TfR). Using a panel of HFE and TfR monoclonal antibodies to examine human HFE (hHFE)-expressing cell lines, we demonstrate the expression of stable and fully glycosylated TfR-free and TfR-associated hHFE/beta2m complexes. We show that both the stability and assembly of hHFE complexes can be modified by the human cytomegalovirus (HCMV) viral protein US2, known to interfere with the expression of classical class I MHC molecules. HCMV US2, but not US11, targets HFE molecules for degradation by the proteasome. Whether this interference with the regulation of iron metabolism by a viral protein is a means of potentiating viral replication remains to be determined. The reduced expression of classical class I MHC and HFE complexes provides the virus with an efficient tool for altering cellular metabolism and escaping certain immune responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.