ArticleJournal of virology2001
Host RNA polymerase requirements for transcription of the human hepatitis delta virus genome.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
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- The Last Universal Common Ancestor of Ribosome-Encoding Organisms: Portrait of LUCA.Journal of molecular evolution · 2024Review
- Review
- Chronic hepatitis delta: A state-of-the-art review and new therapies.World journal of gastroenterology · 2019Review
- ICTV Virus Taxonomy Profile: Deltavirus.The Journal of general virology · 2018Article
- Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus.World journal of gastroenterology · 2014Article
- Searching for nuclear export elements in hepatitis D virus RNA.World journal of virology · 2013Article
- Identification of a binding site for ASF/SF2 on an RNA fragment derived from the hepatitis delta virus genome.PloS one · 2013Article
- Article
- Phosphorylation of serine 177 of the small hepatitis delta antigen regulates viral antigenomic RNA replication by interacting with the processive RNA polymerase II.Journal of virology · 2010Article
- Hepatitis delta virus RNA replication.Viruses · 2009Article
- Intracellular localization of hepatitis delta virus proteins in the presence and absence of viral RNA accumulation.Journal of virology · 2009Article
- Hepatitis delta antigen requires a minimum length of the hepatitis delta virus unbranched rod RNA structure for binding.Journal of virology · 2009Article
- ERK1/2-mediated phosphorylation of small hepatitis delta antigen at serine 177 enhances hepatitis delta virus antigenomic RNA replication.Journal of virology · 2008Article
- Transcription of subgenomic mRNA of hepatitis delta virus requires a modified hepatitis delta antigen that is distinct from antigenomic RNA synthesis.Journal of virology · 2008Article
- Transcription of hepatitis delta virus RNA by RNA polymerase II.Journal of virology · 2008Article
- Nucleolar targeting of hepatitis delta antigen abolishes its ability to initiate viral antigenomic RNA replication.Journal of virology · 2008Article
- RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies.Journal of virology · 2006Article
- Action of inhibitors on accumulation of processed hepatitis delta virus RNAs.Journal of virology · 2006Article
- RNA replication without RNA-dependent RNA polymerase: surprises from hepatitis delta virus.Journal of virology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Replication of the genome of hepatitis delta virus (HDV) requires RNA-directed RNA synthesis using a host polymerase(s). This manuscript reviews the relevant published evidence. It also provides two new studies, both of which made use of transiently transfected Huh7 cells undergoing HDV RNA-directed RNA synthesis. For the first study, RNA transcription inhibitors were added to the transfected cells for periods of 1 to 2 days, after which assays of the effects on the accumulation of processed unit-length genomic HDV RNA were performed. For the second study, nuclei were isolated at 6 days after transfection, and then in vitro runoff transcription was used to assay the effects of RNA transcription inhibitors. Overall, the data support the interpretation that HDV transcription does not require host polymerase I or III (pol I or III) but at least primarily involves an enzyme resembling pol II.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.