ArticleThe Journal of experimental medicine2001
Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- RHOA at the intersection of inflammation-driven and sporadic colorectal cancer.Frontiers in immunology · 2026Review
- Thymic egress and peripheral T cell homeostasis regulated by Rho GTPase-activating protein 30.Cell death and differentiation · 2025Article
- Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine.Cancer biology & medicine · 2024Review
- Immunosenescence: molecular mechanisms and diseases.Signal transduction and targeted therapy · 2023Review
- RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?Precision clinical medicine · 2021Article
- Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.Frontiers in immunology · 2021Article
- RhoA/Rho-kinases in asthma: from pathogenesis to therapeutic targets.Clinical & translational immunology · 2020Review
- mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.Science advances · 2020Article
- Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation.Journal of leukocyte biology · 2019Article
- RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice.Blood · 2018Article
- Rho signaling research: history, current status and future directions.FEBS letters · 2018Review
- Article
- The spectrum of T cell metabolism in health and disease.Nature reviews. Immunology · 2018Review
- RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.Frontiers in immunology · 2018Article
- The curious origins of angioimmunoblastic T-cell lymphoma.Current opinion in hematology · 2016Review
- RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation.The Journal of allergy and clinical immunology · 2016Article
- Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.PloS one · 2015Article
- Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- ROCKs as immunomodulators of stroke.Expert opinion on therapeutic targets · 2012Review
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of function of the guanine nucleotide binding protein RhoA blocks pre-T cell differentiation and survival indicating that this GTPase is a critical signaling molecule during early thymocyte development. Previous work has shown that the Rho family GTPase Rac-1 can initiate changes in actin dynamics necessary and sufficient for pre-T cell development. The present data now show that Rac-1 actions in pre-T cells require Rho function but that RhoA cannot substitute for Rac-1 and induce the actin cytoskeletal changes necessary for pre-T cell development. Activation of Rho is thus not sufficient to induce pre-T cell differentiation or survival in the absence of the pre-T cell receptor (TCR). The failure of RhoA activation to impact on pre-TCR-mediated signaling was in marked contrast to its actions on T cell responses mediated by the mature TCR alpha/beta complex. Cells expressing active RhoA were thus hyperresponsive in the context of TCR-induced proliferation in vitro and in vivo showed augmented positive selection of thymocytes expressing defined TCR complexes. This reveals that RhoA function is not only important for pre-T cells but also plays a role in determining the fate of mature T cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.