ArticleInflammation2001
Cell-cell contacts with epithelial cells modulate the phenotype of human macrophages.
Article in Inflammation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Review
- M1/M2 macrophages and their overlaps - myth or reality?Clinical science (London, England : 1979) · 2023Article
- Mechanisms of the lipopolysaccharide-induced inflammatory response in alveolar epithelial cell/macrophage co-culture.Experimental and therapeutic medicine · 2020Article
- Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells toMediators of inflammation · 2018Article
- Role of heterogeneous cell population on modulation of dendritic cell phenotype and activation of CD8 T cells for use in cell-based immunotherapies.Cellular immunology · 2017Article
- Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to studyNPJ microgravity · 2017Article
- Article
- Cytokine gene expression profile in monocytic cells after a co-culture with epithelial cells.Immunologic research · 2012Article
- Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages.Immunobiology · 2011Article
- Distribution and expression of CD200 in the rat respiratory system under normal and endotoxin-induced pathological conditions.Journal of anatomy · 2010Article
- Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice.American journal of respiratory cell and molecular biology · 2009Article
- Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine.American journal of respiratory cell and molecular biology · 2008Article
- Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages.American journal of respiratory cell and molecular biology · 2007Article
- Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8 release.Inflammation · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial epithelial cells (HBECs), the alveolar type II-like cell line A549, renal adenocarcinoma epithelial cells (RA), and the lung fibroblast strain HFL-1. The expression of CD11b, CD14, CD54, and HLA-DR was measured by immunocytochemistry and flow cytometry and showed epithelial cell induction of CD54 and HLA-DR in monocytes and of all antigens in THP-1 cells. Co-culture with fibroblasts did not change the phenotype of macrophages. Separation by a filter insert inhibited most of the effects. Culture supernatants did not induce prominent phenotypic changes. Cell-cell contacts with epithelium appear to be of importance in regulating the phenotype of macrophages.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.