ArticleThe Journal of physiology2001
Rapidly inactivating and non-inactivating calcium-activated potassium currents in frog saccular hair cells.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- Secondhand Smoke Exposure Impairs Ion Channel Function and Contractility of Mesenteric Arteries.Function (Oxford, England) · 2021Article
- Heat pulse excitability of vestibular hair cells and afferent neurons.Journal of neurophysiology · 2016Article
- BK channel inactivation gates daytime excitability in the circadian clock.Nature communications · 2016Article
- Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle.Frontiers in cellular neuroscience · 2015Article
- Temperature enhances activation and inactivation kinetics of potassium currents in inner hair cells isolated from Guinea-pig cochlea.Clinical and experimental otorhinolaryngology · 2013Article
- Two distinct channels mediated by m2mAChR and α9nAChR co-exist in type II vestibular hair cells of guinea pig.International journal of molecular sciences · 2013Article
- Release and elementary mechanisms of nitric oxide in hair cells.Journal of neurophysiology · 2010Article
- Monitoring transient Ca2+ dynamics with large-conductance Ca2+-dependent K+ channels at active zones in frog saccular hair cells.Neuroscience · 2010Article
- Spikes and membrane potential oscillations in hair cells generate periodic afferent activity in the frog sacculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Ionic composition of endolymph and perilymph in the inner ear of the oyster toadfish, Opsanus tau.The Biological bulletin · 2008Article
- Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminals.The Journal of physiology · 2006Article
- Ca2+-independent activation of BKCa channels at negative potentials in mammalian inner hair cells.The Journal of physiology · 2005Article
- Hair-cell versus afferent adaptation in the semicircular canals.Journal of neurophysiology · 2005Article
- Spontaneous low-frequency voltage oscillations in frog saccular hair cells.The Journal of physiology · 2004Article
- Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells.The Journal of physiology · 2004Article
- Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Rapidly inactivating and non-inactivating calcium-activated potassium currents in frog saccular hair cells.The Journal of physiology · 2001Article
- Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Using a semi-intact epithelial preparation we examined the Ca(2+)-activated K(+) (K(Ca)) currents of frog (Rana pipiens) saccular hair cells. After blocking voltage-dependent K(+) (K(V)) currents with 4-aminopyridine (4-AP) an outward current containing inactivating (I(transient)) and non-inactivating (I(steady)) components remained. 2. The contribution of each varied greatly from cell to cell, with I(transient) contributing from 14 to 90 % of the total outward current. Inactivation of I(transient) was rapid (tau approximately 2-3 ms) and occurred within the physiological range of membrane potentials (V(1/2) = -63 mV). Recovery from inactivation was also rapid (tau approximately 10 ms). 3. Suppression of both I(transient) and I(steady) by depolarizations that approached the Ca(2+) equilibrium potential and by treatments that blocked Ca(2+) influx (application Ca(2+)-free saline or Cd(2+)), suggest both are Ca(2+) dependent. Both were blocked by iberiotoxin, a specific blocker of large-conductance K(Ca) channels (BK), but not by apamin, a specific blocker of small-conductance K(Ca) channels. 4. Ensemble-variance analysis showed that I(transient) and I(steady) flow through two distinct populations of channels, both of which have a large single-channel conductance (~100 pS in non-symmetrical conditions). Together, these data indicate that both I(transient) and I(steady) are carried through BK channels, one of which undergoes rapid inactivation while the other does not. 5. Inactivation of I(transient) could be removed by extracellular papain and could later be restored by intracellular application of the 'ball' domain of the auxiliary subunit (beta2) thought to mediate BK channel inactivation in rat chromaffin cells. We hypothesize that I(transient) results from the association of a similar beta subunit with some of the BK channels and that papain removes inactivation by cleaving extracellular sites required for this association.
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