Trial reportMediators of inflammation2001
Effects after inhalation of (1-->3)-beta-D-glucan in healthy humans.
Trial report in Mediators of inflammation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 51 citations in OpenAlex.
- Effects after inhalation of (1-->3)-beta-D-glucan and relation to mould exposure in the home.Mediators of inflammation · 2002Trial
- Inhalable dust, endotoxins and (1-3)-β-d-glucans as indicators of exposure in waste sorting plant environment.Aerobiologia · 2017Article
- Urban Enhancement of PMJournal of geophysical research. Atmospheres : JGR · 2016Article
- Article
- Assessment of the total inflammatory potential of bioaerosols by using a granulocyte assay.Applied and environmental microbiology · 2009Article
- Airborne fungal and bacterial components in PM1 dust from biofuel plants.The Annals of occupational hygiene · 2009Article
- Treatment of fungal bioaerosols by a high-temperature, short-time process in a continuous-flow system.Applied and environmental microbiology · 2009Article
- Meeting Abstracts. Recent Developments in 1,3-beta-Glucan Biology: Proceedings of the 5th Glucan Symposium Tokyo, December 8, 2006.Mediators of inflammation · 2007Article
- (1-->3)-beta-D-glucan does not induce acute inflammation after nasal deposition.Mediators of inflammation · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimThis study was performed to assess the effects of an exposure to a pure (1-->3)-beta-D-glucan, a cell wall component of fungi, plants and certain bacteria.
methodsTwenty-one healthy subjects inhaled saline or (1-->3)-beta-D-glucan suspended in saline in a random, double-blind, cross-over design. They were examined before exposure and 24 and 72h afterwards with spirometry, blood sampling and collection of induced sputum. Differential cell counts and eosinophilic cationic protein (ECP) were determined in blood and sputum, and myeloperoxidase (MPO), tumour necrosis factor-alpha (TNF-alpha), and interleukin (IL)-8 and IL-10 were determined in sputum supernatants. TNF-alpha was determined after cultivation of blood mononuclear cells.
resultsIn sputum, inhalation of saline caused a significant increase in ECP and TNF-alpha. (1-->3)-beta-D-Glucan inhalation caused a further increase in these cytokines, although not statistically significantly different from the increase induced by inhalation of saline alone. In blood, the number of eosinophils was significantly decreased 72 h after the challenge with (1-->3)-beta-D-glucan. This effect was not found after the inhalation of saline alone. TNF-alpha production from stimulated blood mononuclear cells was significantly decreased 72 h after the (1-->3)-beta-D-glucan inhalation as compared with the increase induced by saline inhalation.
conclusionsThe results suggest that (1-->3)-beta-D-glucan causes a different type of response as compared with inflammatory agents such as bacterial endotoxin that cause a neutrophil-dominated inflammatory response.
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