ArticleThe Biochemical journal2001
Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 80 citations in OpenAlex.
- Ion-mediated effects of glycosylation on the disordered mucin domain: Insights from coarse-grained simulations.Biophysical journal · 2025Article
- Effect of Dead-CellAnimals : an open access journal from MDPI · 2025Article
- Deep crypt secretory cells shape region-specific mucin glycosylation patterns in the mouse colon.PloS one · 2025Article
- Binding of Akkermansia muciniphila to mucin is O-glycan specific.Nature communications · 2024Article
- The story of the SdGlycoconjugate journal · 2023Review
- Engineered Glycan-Binding Proteins for Recognition of the Thomsen-Friedenreich Antigen and Structurally Related Disaccharides.ACS chemical biology · 2023Article
- Alterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a Saccharomyces cerevisiae fermentation product identify potential regulatory processes.Journal of animal science · 2023Article
- Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure.BMC cancer · 2022Article
- Structural basis for the synthesis of the core 1 structure by C1GalT1.Nature communications · 2022Article
- Glycoproteomic and Phenotypic Elucidation ofInternational journal of molecular sciences · 2022Article
- How microbial glycosyl hydrolase activity in the gut mucosa initiates microbial cross-feeding.Glycobiology · 2022Review
- B4GALNT2 Controls SdChembiochem : a European journal of chemical biology · 2021Review
- The Cancer-Associated Antigens Sialyl LewisCancers · 2021Review
- Sialic acid O-acetylation: From biosynthesis to roles in health and disease.The Journal of biological chemistry · 2021Review
- Display of the human mucinome with defined O-glycans by gene engineered cells.Nature communications · 2021Article
- Glycosyltransferase B4GALNT2 as a Predictor of Good Prognosis in Colon Cancer: Lessons from Databases.International journal of molecular sciences · 2021Article
- Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype.Cellular and molecular life sciences : CMLS · 2021Article
- Mucins and the Microbiome.Annual review of biochemistry · 2020Review
- A Sensitive and Rapid Method to Determin the Adhesion Capacity of Probiotics and Pathogenic Microorganisms to Human Gastrointestinal Mucins.Microorganisms · 2018Article
- Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAcbeta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.