ArticleMolecular pathology : MP2001
Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas.
Article in Molecular pathology : MP, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- JC virus small tumor antigen promotes S phase entry and cell cycle progression.Tumour virus research · 2024Article
- Detection of human neurotropic JCPyV DNA sequence in pediatric anaplastic xanthoastrocytoma.Journal of neurovirology · 2023Article
- Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway.Molecular cancer research : MCR · 2022Article
- The Role of the JC Virus in Central Nervous System Tumorigenesis.International journal of molecular sciences · 2020Review
- Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Review
- Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis.Frontiers in oncology · 2019Review
- Review on the role of the human Polyomavirus JC in the development of tumors.Infectious agents and cancer · 2017Review
- Detection of human JCPyV and BKPyV in diffuse large B-cell lymphoma of the GI tract.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Medulloblastoma-biology and microenvironment: a review.Pediatric hematology and oncology · 2012Review
- Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.Clinical microbiology reviews · 2012Review
- Chronic viral infection and primary central nervous system malignancy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma.Journal of cellular biochemistry · 2010Article
- JC virus-induced Progressive Multifocal Leukoencephalopathy.Future virology · 2010Article
- pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda.BMC clinical pathology · 2009Article
- JC virus: an oncogenic virus in animals and humans?Seminars in cancer biology · 2009Review
- The role of viral and bacterial pathogens in gastrointestinal cancer.Journal of cellular physiology · 2008Review
- Medulloblastoma: from molecular pathology to therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Review
- Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses.Oncogene · 2006Review
- Review
- Analysis of the excreted JC virus strains and their potential oral transmission.Journal of neurovirology · 2003Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsAlthough the aetiology of medulloblastoma remains elusive, several lines of evidence suggest an association with the human neurotropic polyomavirus JC and its oncoprotein T antigen. The tumour forming properties of JC virus T antigen are the result, at least in part, of its ability to bind and inactivate tumour suppressor/cell cycle regulatory proteins, such as p53 and the retinoblastoma family of proteins.
methodsTo examine potential relations between these factors, immunohistochemistry was used to determine associations between the T antigen and the expression of p53 and the retinoblastoma proteins pRb, p107, and Rb2/p130 in eight medulloblastomas.
resultsOnly the three medulloblastomas with T antigen expression also showed nuclear positivity with antibodies to p53. Although immunohistochemistry detected nuclear labelling for pRb in five of the cases, the three that were positive for T antigen showed the highest pRb labelling. The retinoblastoma related proteins p107 and Rb2/p130 were also immunopositive in most T antigen positive medulloblastomas. Double label immunohistochemistry also demonstrated p53 and pRb positivity in the same cells that were T antigen positive.
conclusionsThese correlations suggest that associations between T antigen and p53 and/or T antigen and pRb occur in some of these tumours. These data provide indirect evidence that JC virus, acting through T antigen, might be involved in the formation and progression of medulloblastoma.
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