ArticleAllergy2001
Prolonged nasal eosinophilia in allergic patients after common cold.
Article in Allergy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Postmarketing Reevaluation of Chinese Traditional Therapy Kangbingdu Oral Liquid in the Treatment of the Common Cold.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16.The Journal of allergy and clinical immunology · 2009Article
- Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2009Article
- Respiratory viruses and eosinophils: exploring the connections.Antiviral research · 2009Review
- Host immune responses to rhinovirus: mechanisms in asthma.The Journal of allergy and clinical immunology · 2008Review
- Understanding the mechanisms of viral induced asthma: new therapeutic directions.Pharmacology & therapeutics · 2008Review
- Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response.The Journal of allergy and clinical immunology · 2006Review
- Age- and infection-related maturation of the nasal immune response in 0-2-year-old children.Allergy · 2005Article
- Mechanisms of rhinovirus-induced asthma.Paediatric respiratory reviews · 2004Review
- Host defense function of the airway epithelium in health and disease: clinical background.Journal of leukocyte biology · 2004Review
- Rhinoviruses in the pathogenesis of asthma.Current allergy and asthma reports · 2003Review
- Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.Pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViral respiratory tract infections may cause both harmless common colds and severe asthma exacerbations; the differences in disease expression probably depend on the allergic status of the patient. To determine whether altered immunologic mechanisms underlie these differences, we investigated nasal inflammation during naturally acquired common cold.
methodsIn a group of 16 patients (eight allergic), nasal brush samples were taken, and nasal symptoms were recorded during common cold, 2 weeks later (convalescence), and at baseline (>4 weeks without nasal symptoms). Nasal brush cells were stained immunohistochemically for Langerhans cells, T cells, monocytes, neutrophils, B cells, macrophages, natural killer (NK) cells, mast cells, eosinophils, eotaxin, and RANTES.
resultsFour rhinovirus, four coronavirus, three RSV, one Mycoplasma pneumoniae, and one influenza A/enterovirus double infection were confirmed. Increased numbers of T cells, monocytes, macrophages, NK cells, eosinophils, and RANTES- and eotaxin-positive cells, but not neutrophils, were observed during common cold in allergic and nonallergic patients, and increased numbers of mast cells in allergic patients. Compared to nonallergic patients, in allergic patients eosinophil influx persisted into convalescence.
conclusionProlonged nasal eosinophil influx was observed in allergic patients after common cold. What immunologic factors can induce prolonged eosinophil influx and whether this may increase the risk of subsequent allergen-induced hypersensitivity reactions must be studied further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.