ArticleThe Journal of infectious diseases2001
Human immunodeficiency virus type 1 reverse-transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population.
Article in The Journal of infectious diseases, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 88 citations in OpenAlex.
- HIV-1 subtype diversity trends in a Northern California cohort.AIDS (London, England) · 2026Article
- Non-B variants of HIV-1 in San Francisco, California.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Phylogenetic and geospatial evaluation of HIV-1 subtype diversity at the largest HIV center in Rhode Island.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- Large-scale analysis of the prevalence and geographic distribution of HIV-1 non-B variants in the United States.Journal of clinical microbiology · 2013Article
- A template-dependent dislocation mechanism potentiates K65R reverse transcriptase mutation development in subtype C variants of HIV-1.PloS one · 2011Article
- Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.Retrovirology · 2010Article
- Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.Journal of virology · 2008Article
- Analysis of correlated mutations in HIV-1 protease using spectral clustering.Bioinformatics (Oxford, England) · 2008Article
- Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers.Nucleic acids research · 2007Article
- Web resources for HIV type 1 genotypic-resistance test interpretation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2006Article
- Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samples.Biology direct · 2006Article
- Use of sequence data generated in the Bayer Tru Gene genotyping assay to recognize and characterize non-subtype-b human immunodeficiency virus type 1 strains.Journal of clinical microbiology · 2005Article
- High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.Journal of virology · 2005Article
- Drug resistance and antiretroviral drug development.The Journal of antimicrobial chemotherapy · 2005Review
- Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration.PLoS medicine · 2005Article
- Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.Antimicrobial agents and chemotherapy · 2004Article
- Natural variation of drug susceptibility in wild-type human immunodeficiency virus type 1.Antimicrobial agents and chemotherapy · 2004Article
- Protease and reverse transcriptase mutation patterns in HIV type 1 isolates from heavily treated persons: comparison of isolates from Northern California with isolates from other regions.AIDS research and human retroviruses · 2003Article
- Lack of detectable human immunodeficiency virus type 1 superinfection during 1072 person-years of observation.The Journal of infectious diseases · 2003Article
- HIV-1 protease and reverse transcriptase mutation patterns responsible for discordances between genotypic drug resistance interpretation algorithms.Journal of acquired immune deficiency syndromes (1999) · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Phylogenetic analysis of the reverse transcriptase (RT) and protease of 117 published complete human immunodeficiency virus (HIV) type 1 genome sequences demonstrated that these genes cluster into distinct subtypes. There was a slightly higher proportion of informative sites in the RT (40.4%) than in the protease (34.8%; P= .03). Although most variation between subtypes was due to synonymous nucleotide substitutions, several subtype-specific amino acid patterns were observed. In the protease, the subtype-specific variants included 7 positions associated with drug resistance. Variants at positions 10, 20, 36, and 82 were more common in non-B isolates, whereas variants at positions 63, 77, and 93 were more common in subtype B isolates. In the RT, the subtype-specific mutations did not include positions associated with anti-retroviral drug resistance. RT and protease sequences from 2246 HIV-infected persons in northern California were also examined: 99.4% of the sequences clustered with subtype B, whereas 0.6% clustered with subtype A, C, or D.
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