ArticleNucleic acids research2001
Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 88 citations in OpenAlex.
- Multifaceted Interactions Between Bile Acids, Their Receptors, and MASH: From Molecular Mechanisms to Clinical Therapeutics.Molecules (Basel, Switzerland) · 2025Review
- Gut microbiota depletion aggravates bile acid-induced liver pathology in mice with a human-like bile acid composition.Clinical science (London, England : 1979) · 2023Article
- A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling.Molecules (Basel, Switzerland) · 2022Review
- Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.Hepatology communications · 2018Article
- Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation.The Journal of pharmacy and pharmacology · 2016Article
- Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice.PloS one · 2014Article
- Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor in Ldlr -/- mice versus hamsters.Journal of lipid research · 2013Article
- Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription.PloS one · 2013Article
- Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.The Journal of biological chemistry · 2012Article
- Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Farnesoid X receptor represses hepatic human APOA gene expression.The Journal of clinical investigation · 2011Article
- Emerging actions of the nuclear receptor LRH-1 in the gut.Biochimica et biophysica acta · 2011Review
- Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor.Journal of lipid research · 2011Article
- ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression.The Journal of biological chemistry · 2007Article
- Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.The EMBO journal · 2005Article
- Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis.The Journal of clinical investigation · 2003Article
- Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.Molecular and cellular biology · 2003Article
- Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.Genes & development · 2003Article
- Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.EMBO reports · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cholesterol conversion to bile acids is subject to a feedback regulatory mechanism by which bile acids down-regulate their own synthesis. This regulation occurs at the level of transcription of several genes encoding enzymes in the bile acid biosynthetic pathway. One of these enzymes is sterol 12alpha-hydroxylase/CYP8B1 (12alpha-hydroxylase), the specific enzyme required for cholic acid synthesis. The levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrophobicity of the circulating bile acid pool. Previous studies from this laboratory showed that fetoprotein transcription factor (FTF) is required for 12alpha-hydroxylase promoter activity and bile acid-mediated regulation. Here, we report that the short heterodimer partner (SHP) suppresses 12alpha-hydroxylase promoter activity via an interaction with FTF. Hepatic nuclear factor-4 (HNF-4) binds and activates the 12alpha-hydroxylase promoter and is required for 12alpha-hydroxylase promoter activity. Although HNF-4 interacts with SHP, it is not involved in SHP-mediated suppression of 12alpha-hydroxylase promoter activity. FTF and not HNF-4 is the factor involved in regulation of 12alpha-hydroxylase promoter activity by bile acids through its interaction with SHP. Finally, interaction of SHP with FTF displaces FTF binding to its sites within the 12alpha-hydroxylase promoter. These results provide insights into the mechanism of action of bile acid-mediated regulation of sterol 12alpha-hydroxylase transcription.
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