ArticleNucleic acids research2001
An active retrotransposon in Candida albicans.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- A systematic screen for co-option of transposable elements across the fungal kingdom.Mobile DNA · 2024Article
- Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective.Mobile DNA · 2020Review
- Comparative metatranscriptome analysis revealed broad response of microbial communities in two soil types, agriculture versus organic soil.Journal, genetic engineering & biotechnology · 2019Article
- Superior ab initio identification, annotation and characterisation of TEs and segmental duplications from genome assemblies.PloS one · 2018Article
- Sequence Assembly of Yarrowia lipolytica Strain W29/CLIB89 Shows Transposable Element Diversity.PloS one · 2016Article
- Genetic and phenotypic intra-species variation in Candida albicans.Genome research · 2015Article
- The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.Virulence · 2014Review
- A core filamentation response network in Candida albicans is restricted to eight genes.PloS one · 2013Article
- Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans.BMC microbiology · 2008Article
- Control of gag-pol gene expression in the Candida albicans retrotransposon Tca2.BMC molecular biology · 2007Article
- A yeast model for target-primed (non-LTR) retrotransposition.BMC genomics · 2007Article
- Loss and fragmentation of chromosome 5 are major events linked to the adaptation of rad52-DeltaDelta strains of Candida albicans to sorbose.Fungal genetics and biology : FG & B · 2007Article
- Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.Eukaryotic cell · 2007Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tca2 is a Ty1/copia-type retrotransposon from the pathogenic yeast Candida albicans. It was originally identified as an abundant, linear, extrachromosomal, double-stranded DNA molecule. Here we show that Tca2 is widespread in C.albicans, but that the abundance of extrachromosomal Tca2 DNA varies greatly among different strains and is strongly dependent on the growth temperature. The relative levels of Tca2 RNA vary in a similar pattern to the extrachromosomal DNA, raising the possibility that the variations in extrachromosomal DNA levels are introduced predominantly at the level of transcription. We have also analysed the retrotranspositional activity of the element by developing a transposition assay involving a cloned Tca2 element tagged with a selectable marker gene that is activated by passage through an RNA intermediate. We show that the marked Tca2 is transpositionally active as transposed copies of the marked element became integrated at a variety of new positions in the genome and an intron in the donor element was precisely removed in the newly transposed copies. This is the first report of transposition in C.albicans.
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