ArticleJournal of clinical microbiology2001
Great diversity of group A rotavirus strains and high prevalence of mixed rotavirus infections in India.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 142 citations in OpenAlex.
- Phase III randomized clinical studies to evaluate the immunogenicity, lot-to-lot consistency, and safety of ROTAVAC® liquid formulations (ROTAVAC 5C & 5D) and non-inferiority comparisons with licensed ROTAVAC® (frozen formulation) in healthy infants.Human vaccines & immunotherapeutics · 2023Trial
- A Phase 4, multicentre, randomized, single-blind clinical trial to evaluate the immunogenicity of the live, attenuated, oral rotavirus vaccine (116E), ROTAVAC®, administered simultaneously with or without the buffering agent in healthy infants in India.Human vaccines & immunotherapeutics · 2018Trial
- Epidemiology of Acute Gastroenteritis Caused by Rotavirus among Children Less than Five Years Old Admitted in Hospital, in North India.Indian journal of pediatrics · 2021Article
- Whole-Genome Analyses Identifies Multiple Reassortant Rotavirus Strains in Rwanda Post-Vaccine Introduction.Viruses · 2021Article
- Rotavirus in Calves and Its Zoonotic Importance.Veterinary medicine international · 2021Review
- Genotypic determination of human group A rotaviruses from Goa and Meghalaya states, India.Heliyon · 2020Article
- Intragenic recombination influences rotavirus diversity and evolution.Virus evolution · 2020Article
- Genotyping of Rotaviruses in River Nile in Giza, Egypt.Iranian journal of public health · 2020Article
- A universal genome sequencing method for rotavirus A from human fecal samples which identifies segment reassortment and multi-genotype mixed infection.BMC genomics · 2017Article
- Characterization of a triple-recombinant, reassortant rotavirus strain from the Dominican Republic.The Journal of general virology · 2017Article
- Continuous detection and genetic diversity of human rotavirus A in sewage in eastern China, 2013-2014.Virology journal · 2016Article
- Genetic diversity of porcine group A rotavirus strains in the UK.Veterinary microbiology · 2014Article
- Pathogenicity of porcine G9P[23] and G9P[7] rotaviruses in piglets.Veterinary microbiology · 2013Article
- Rotavirus genotypes associated with childhood severe acute diarrhoea in southern Ghana: a cross-sectional study.Virology journal · 2013Article
- Article
- Burden and typing of rotavirus group a in children with acute gastroenteritis in shiraz, southern iran.Iranian Red Crescent medical journal · 2012Article
- Molecular epidemiology of group A human rotaviruses in North West region, Cameroon.The Pan African medical journal · 2012Article
- Detection and genotyping of Korean porcine rotaviruses.Veterinary microbiology · 2010Article
- Characterization of group A rotavirus infections in adolescents and adults from Pune, India: 1993-1996 and 2004-2007.Journal of medical virology · 2010Article
- Detection and genotyping of human rotavirus VP4 and VP7 genes by reverse transcriptase PCR and reverse hybridization.Journal of clinical microbiology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously observed a marked diversity of rotavirus strains and a high prevalence of the uncommon serotype G9 in a small survey of rotavirus strains collected from six centers in India. In the present study, we characterized a larger collection of strains from children hospitalized with severe diarrhea in seven Indian cities between 1996 and 1998. A total of 287 strains were G and P genotyped by reverse transcription-PCR, and some were further characterized by electropherotyping and subgrouping. Of the four strains common globally, three were found in only 43% of samples (P[8], G1, 15%; P[4], G2, 22%; P[8], G4, 6%), whereas G9 strains made up 17% of the total. Three different G9 strains were present: a P[8], G9 strain, which displayed the long electropherotype and subgroup II VP6 specificity, and two P[6], G9 strains, one with the long electropherotype and subgroup II specificity and the other with the short electropherotype and subgroup I specificity. Marked diversity was observed among strains collected from different cities and collected over time. Of the 253 strains that were fully typed, 54 (21%) had a mixed G or P genotype. Serotype G2 strains were detected more often in infections caused by single strains than in mixed infections (P < 0.05), whereas serotype G1 strains were found more often in mixed infections than in infections caused by single strains (P < 0.05). The diversity of rotavirus strains and the high prevalence of mixed infections confirm trends reported earlier and help to better characterize the strains of rotavirus circulating in India. Vaccines under development should clearly target G9 strains, and G9 should be included as one of the common global serotypes.
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