ArticleProceedings of the National Academy of Sciences of the United States of America2001
Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 255 papers, 3 of them syntheses that pooled it.
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Who cites it
255 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- Alterations of the occipital lobe in schizophrenia.Neurosciences (Riyadh, Saudi Arabia) · 2015Pooled it
- Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting.Schizophrenia bulletin · 2011Pooled it
- Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis.JAMA psychiatry · 2023Trial
- Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Adjusting brain dynamics in schizophrenia by means of perceptual and cognitive training.PloS one · 2012Trial
- Trial
- Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia.Molecular psychiatry · 2011Trial
- Time-lapse mapping of cortical changes in schizophrenia with different treatments.Cerebral cortex (New York, N.Y. : 1991) · 2009Trial
- Remission status and cortical thickness in childhood-onset schizophrenia.Journal of the American Academy of Child and Adolescent Psychiatry · 2008Trial
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- Schizophrenia as a Disorder of Biological Barriers: A Narrative Review and Potential Interventions.International journal of molecular sciences · 2026Review
- Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Subtyping schizophrenia via machine learning by using structural neuroimaging.Translational psychiatry · 2025Review
- Neurocognitive dysfunctions in childhood-onset schizophrenia: A systematic review.Schizophrenia research. Cognition · 2025Review
- Reduced Cerebellar Volumes Associate with P300 Amplitude Attenuation in Children with Clinical High Risk for Psychosis and Early Onset Psychosis.Cerebellum (London, England) · 2025Article
- Interactive effects of social media use and puberty on resting-state cortical activity and mental health symptoms.Developmental cognitive neuroscience · 2025Article
- Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.Nature communications · 2024Article
- Age-related change in cortical thickness in adolescents at clinical high risk for psychosis: a longitudinal study.European child & adolescent psychiatry · 2024Article
195 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Neurodevelopmental models for the pathology of schizophrenia propose both polygenetic and environmental risks, as well as early (pre/perinatal) and late (usually adolescent) developmental brain abnormalities. With the use of brain mapping algorithms, we detected striking anatomical profiles of accelerated gray matter loss in very early-onset schizophrenia; surprisingly, deficits moved in a dynamic pattern, enveloping increasing amounts of cortex throughout adolescence. Early-onset patients were rescanned prospectively with MRI, at 2-year intervals at three time points, to uncover the dynamics and timing of disease progression during adolescence. The earliest deficits were found in parietal brain regions, supporting visuospatial and associative thinking, where adult deficits are known to be mediated by environmental (nongenetic) factors. Over 5 years, these deficits progressed anteriorly into temporal lobes, engulfing sensorimotor and dorsolateral prefrontal cortices, and frontal eye fields. These emerging patterns correlated with psychotic symptom severity and mirrored the neuromotor, auditory, visual search, and frontal executive impairments in the disease. In temporal regions, gray matter loss was completely absent early in the disease but became pervasive later. Only the latest changes included dorsolateral prefrontal cortex and superior temporal gyri, deficit regions found consistently in adult studies. These emerging dynamic patterns were (i) controlled for medication and IQ effects, (ii) replicated in independent groups of males and females, and (iii) charted in individuals and groups. The resulting mapping strategy reveals a shifting pattern of tissue loss in schizophrenia. Aspects of the anatomy and dynamics of disease are uncovered, in a changing profile that implicates genetic and nongenetic patterns of deficits.
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