ArticleProceedings of the National Academy of Sciences of the United States of America2001
SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 140 citations in OpenAlex.
- The role of viruses in cancer development versus cancer therapy: An oncological perspective.Cancer medicine · 2023Review
- BAP1 is a novel regulator of HIF-1α.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- SV40 and human mesothelioma.Translational lung cancer research · 2020Review
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- Target therapy: new drugs or new combinations of drugs in malignant pleural mesothelioma.Journal of thoracic disease · 2018Review
- DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.International journal of oncology · 2017Article
- Review
- Switching off malignant mesothelioma: exploiting the hypoxic microenvironment.Genes & cancer · 2016Review
- P2X7 targeting inhibits growth of human mesothelioma.Oncotarget · 2016Article
- Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma.Oncotarget · 2015Article
- An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells.PloS one · 2015Article
- MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion.BioMed research international · 2015Article
- HGF/Met Signaling Is a Key Player in Malignant Mesothelioma Carcinogenesis.Biomedicines · 2014Review
- Review
- Agonist activation of estrogen receptor beta (ERβ) sensitizes malignant pleural mesothelioma cells to cisplatin cytotoxicity.Molecular cancer · 2014Article
- Increased levels of C-C chemokine RANTES in asbestos exposed workers and in malignant mesothelioma patients from an hyperendemic area.PloS one · 2014Article
- Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2.BMC complementary and alternative medicine · 2013Article
- Serological evidence of an early seroconversion to Simian virus 40 in healthy children and adolescents.PloS one · 2013Article
- High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma.British journal of pharmacology · 2012Review
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggested that simian virus 40 (SV40) may cause malignant mesothelioma, although the pathogenic mechanism is unclear. We found that in SV40-positive malignant mesothelioma cells, the hepatocyte growth factor (HGF) receptor (Met) was activated. In human mesothelial cells (HMC) transfected with full-length SV40 DNA (SV40-HMC), Met receptor activation was associated with S-phase entry, acquisition of a fibroblastoid morphology, and the assembly of viral particles. Coculture experiments revealed the ability of SV40-HMC to infect permissive monkey cells (CV-1), HMC, and murine BNL CL cells. Cocultured human and murine SV40-positive cells expressed HGF, showed Met tyrosine phosphorylation and S-phase entry, and acquired a spindle-shaped morphology (spBNL), whereas CV-1 cells were lysed. Cocultured HMC inherited from SV40-HMC the infectivity, as they induced lysis in cocultured CV-1 cells. Treatment with suramin or HGF-blocking antibodies inhibited Met tyrosine phosphorylation in all large T antigen (Tag)-positive cells and reverted the spindle-shaped morphology of spBNL. This finding indicated that Met activation and subsequent biological effects were mediated by an autocrine HGF circuit. This, in turn, was causally related to Tag expression, being induced by transfection with the SV40 early region alone. Our findings suggest that when SV40 infects HMC it causes Met activation via an autocrine loop. Furthermore, SV40 replicates in HMC and infects the adjacent HMC, inducing an HGF-dependent Met activation and cell-cycle progression into S phase. This may explain how a limited number of SV40-positive cells may be sufficient to direct noninfected HMC toward malignant transformation.
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