ArticleNeoplasia (New York, N.Y.)
Global methylation profiling of lung cancer identifies novel methylated genes.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 84 citations in OpenAlex.
- A prognostic predictor panel with DNA methylation biomarkers for early-stage lung adenocarcinoma in Asian and Caucasian populations.Journal of biomedical science · 2016Trial
- Epigenetic changes driven by environmental pollutants in lung carcinogenesis: a comprehensive review.Frontiers in public health · 2024Review
- Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer.BMC genomics · 2017Article
- DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.Cancer cell · 2017Article
- Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.Oncogene · 2013Article
- Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.Molecular cancer · 2012Article
- [Advances of DNA methylation in early diagnosis of lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2012Review
- Article
- Molecular biology of lung cancer: clinical implications.Clinics in chest medicine · 2011Review
- DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma.PloS one · 2011Article
- Genome-wide epigenetic modifications in cancer.Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques · 2011Review
- DNA fingerprinting techniques for the analysis of genetic and epigenetic alterations in colorectal cancer.Mutation research · 2010Review
- [DNA methylation and non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Review
- Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.Cancer metastasis reviews · 2010Review
- Gene expression profile of androgen modulated genes in the murine fetal developing lung.Reproductive biology and endocrinology : RB&E · 2010Article
- Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.Future oncology (London, England) · 2010Review
- Cancer DNA methylation: molecular mechanisms and clinical implications.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Mining the epigenome for methylated genes in lung cancer.Proceedings of the American Thoracic Society · 2008Article
- DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update.Molecular cancer · 2008Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Epigenetic changes, including DNA methylation, are a common finding in cancer. In lung cancers methylation of cytosine residues may affect tumor initiation and progression in several ways, including the silencing of tumor suppressor genes through promoter methylation and by providing the targets for adduct formation of polycyclic aromatic hydrocarbons present in combustion products of cigarette smoke. Although the importance of aberrant DNA methylation is well established, the extent of DNA methylation in lung cancers has never been determined. Restriction landmark genomic scanning (RLGS) is a highly reproducible two-dimensional gel electrophoresis that allows the determination of the methylation status of up to 2000 promoter sequences in a single gel. We selected 1184 CpG islands for RLGS analysis and determined their methylation status in 16 primary non-small cell lung cancers. Some tumors did not show methylation whereas others showed up to 5.3% methylation in all CpG islands of the profile. Cloning of 21 methylated loci identified 11 genes and 6 ESTs. We demonstrate that methylation is part of the silencing process of BMP3B in primary tumors and lung cancer cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.