ArticleGene therapy2001
Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer.
Article in Gene therapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Adenoviral Vectors in Gene Therapy: A Detailed Overview.Iranian biomedical journal · 2026Review
- TP63 Functions as a Tumor Suppressor Regulated by GAS5/miR-221-3p Signaling Axis in Human Non-Small Cell Lung Cancer Cells.Cancer management and research · 2023Article
- Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death.Cancer biology & therapy · 2021Article
- ΔNp63α promotes the expression and nuclear translocation of PTEN, leading to cisplatin resistance in oral cancer cells.American journal of translational research · 2020Article
- Protein-protein interaction analysis of distinct molecular pathways in two subtypes of colorectal carcinoma.Molecular medicine reports · 2014Article
- Transcription factor p63 regulates key genes and wound repair in human airway epithelial basal cells.American journal of respiratory cell and molecular biology · 2013Article
- A novel approach to cancer treatment using structural hybrids of the p53 gene family.Cancer gene therapy · 2012Article
- Chapter seven--Cancer treatment with gene therapy and radiation therapy.Advances in cancer research · 2012Review
- Targeting p53 for Novel Anticancer Therapy.Translational oncology · 2010Article
- Expression and clinical significance of S100A2 and p63 in esophageal carcinoma.World journal of gastroenterology · 2009Article
- CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB.Oncogene · 2009Article
- The role of HRK gene in human cancer.Oncogene · 2008Review
- Cytoplasmic RASSF2A is a proapoptotic mediator whose expression is epigenetically silenced in gastric cancer.Carcinogenesis · 2008Article
- Down-regulation of Wilms' tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53.Journal of neuro-oncology · 2007Article
- Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.Oncogene · 2005Article
- Effect of indomethacin on cell cycle proteins in colon cancer cell lines.World journal of gastroenterology · 2005Article
- The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines.World journal of gastroenterology · 2004Article
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- p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract.The American journal of pathology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 gene therapy is being tested clinically for the treatment of human cancer, however, some cancer models (in vivo and in vitro) are resistant to p53. To explore the potential use of two p53 homologues, p73 and p51/p63, in cancer gene therapy, we introduced p53, p73 and p51/p63 into colorectal cancer cell lines via adenoviral vectors, and compared their effects on cell growth. Among 10 cell lines tested, six cell lines displayed a similar response following transduction of p53, p73beta or p51A/p63gamma; two lines underwent cell-cycle arrest, three lines exhibited apoptosis and one line showed no-effect following transduction. The effect on cell-cycle progression was variable in the other four cell lines. Interestingly, three cell lines were resistant to p53-mediated apoptosis, including two lines having endogenous wild-type p53 alleles, but underwent apoptosis after transduction of p73beta or p51A/p63gamma. Similar to p53, transduction of p51A/p63gamma induced extensive apoptosis when combined with adriamycin or X-radiation in SW480 cells, which are normally resistant to apoptosis. Transduction of p73beta and p51A/p63gamma also reduced the tumorigenicity of two colorectal cancer cells in vivo. These results suggest that adenovirus-mediated p73beta and p51A/p63gamma transfer are potential novel approaches for the treatment of human cancers, particularly for tumors that are resistant to p53 gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.