ArticleThe Laryngoscope2001
Motility-related proteins as markers for head and neck squamous cell cancer.
Article in The Laryngoscope, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 111 citations in OpenAlex.
- Expression Analysis of the Small GTP-Binding Protein Rac in PterygiumTurkish journal of ophthalmology · 2023Article
- New insights into RAS in head and neck cancer.Biochimica et biophysica acta. Reviews on cancer · 2023Review
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- Eugenol Induces Apoptosis in Tongue Squamous Carcinoma Cells by Mediating the Expression of Bcl-2 Family.Life (Basel, Switzerland) · 2022Article
- Activation Mechanism of RhoA Caused by Constitutively Activating Mutations G14V and Q63L.International journal of molecular sciences · 2022Article
- OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer.Journal of experimental & clinical cancer research : CR · 2022Article
- Actin Modulation Regulates the Alpha-1-Syntrophin/p66Shc Mediated Redox Signaling Contributing to the RhoA GTPase Protein Activation in Breast Cancer Cells.Frontiers in oncology · 2022Article
- Effects of isoprenylcysteine carboxylmethyltransferase silencing on the migration and invasion of tongue squamous cell carcinoma.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- A Mechanical Instability in Planar Epithelial Monolayers Leads to Cell Extrusion.Biophysical journal · 2020Article
- Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas.Scientific reports · 2017Article
- Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer.Clinical oral investigations · 2017Article
- Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.Oncotarget · 2017Article
- High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.Digestive diseases and sciences · 2017Article
- Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.Scientific reports · 2017Article
- Genetic variants in RhoA and ROCK1 genes are associated with the development, progression and prognosis of prostate cancer.Oncotarget · 2017Article
- Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression.Brain research · 2016Review
- Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- MERTK as a novel therapeutic target in head and neck cancer.Oncotarget · 2016Article
- LIM domain only 2 induces glioma invasion via cytosolic p27(KIP1).Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The prognostic value of Tiam1 protein expression in head and neck squamous cell carcinoma: a retrospective study.Chinese journal of cancer · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
hypothesisIncreased cell motility is a hallmark of cancer cells. Proteins involved in cell motility may be used as molecular markers to characterize the malignant potential of tumors.
methodsMolecular biology and immunohistochemistry techniques were used to investigate the expression of a selected panel of motility-related proteins (Rho A, Rac 2, Cdc42, PI3K, 2E4, and Arp2) in normal, premalignant, and squamous cell cancer cell lines of human head and neck origin. To assess the clinical potential of these proteins as molecular markers for cancer, immunohistochemistry was performed on paraffin-fixed head and neck cancer specimens (n = 15).
resultsAll six motility-associated proteins were overexpressed in the premalignant and squamous cell cancer cell lines relative to normal keratinocytes. Immunohistochemistry with Rho A and Rac 2 showed increased staining in areas of cancer but not in normal tissue.
conclusionProteins involved in cell motility can be used as markers for head and neck squamous cell carcinoma. The head and neck cell lines used in this study may be used as a model to further investigate cell motility. Molecular markers of motility could have a significant impact on the diagnosis and staging of cancers originating from differentiated non-motile cells.
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