Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2001
Nitric oxide and neurally mediated regulation of skin blood flow during local heating.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02549534 (Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer), which is not on this map. Cited by 263 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Who cites it
263 citing papers in PubMed, 1 synthesis or guideline pooled it, 684 citations in OpenAlex.
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- Salsalate negatively impacts microvascular function in women with endometriosis.American journal of physiology. Heart and circulatory physiology · 2025Trial
- Acute effects of cold, heat and contrast pressure therapy on forearm muscles regeneration in combat sports athletes: a randomized clinical trial.Scientific reports · 2024Trial
- Device-guided slow breathing alters postprandial oxidative stress in young adult males: A randomized sham-controlled crossover trial.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Trial
- ETAmerican journal of physiology. Heart and circulatory physiology · 2021Trial
- Local Passive Heat for the Treatment of Hypertension in Autonomic Failure.Journal of the American Heart Association · 2021Trial
- Four weeks of vitamin D supplementation improves nitric oxide-mediated microvascular function in college-aged African Americans.American journal of physiology. Heart and circulatory physiology · 2020Trial
- Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant humans.American journal of physiology. Heart and circulatory physiology · 2019Trial
- Effects of aerobic exercise on vascular function in nondialysis chronic kidney disease: a randomized controlled trial.American journal of physiology. Renal physiology · 2019Trial
- Effect of direct cold atmospheric plasma (diCAP) on microcirculation of intact skin in a controlled mechanical environment.Microcirculation (New York, N.Y. : 1994) · 2017Trial
- Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes.Scientific reports · 2017Trial
- Mechanisms and time course of menthol-induced cutaneous vasodilation.Microvascular research · 2017Trial
- Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation.Journal of the American Heart Association · 2016Trial
- Topical menthol increases cutaneous blood flow.Microvascular research · 2016Trial
- Forearm Skin Blood Flow After Kinesiology Taping in Healthy Soccer Players: An Exploratory Investigation.Journal of athletic training · 2015Trial
- Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms.Clinical science (London, England : 1979) · 2015Trial
- Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Non-Invasive Measurement of Skin Microvascular Response during Pharmacological and Physiological Provocations.PloS one · 2015Trial
- The effect of acute administration of vitamin D on micro vascular endothelial function in Caucasians and South Asian Indians.Medical science monitor : international medical journal of experimental and clinical research · 2013Trial
203 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanisms underlying the skin blood flow (SkBF) response to local heating are complex and poorly understood. Our goal was to examine the role of axon reflexes and nitric oxide (NO) in the SkBF response to a local heating protocol. We performed 40 experiments following a standardized heating protocol with different interventions, including blockade of the axon reflex (EMLA cream), antebrachial nerve blockade (0.5% bupivacaine injection), and NO synthase (NOS) inhibition (> or =10 mM N(G)-nitro-L-arginine methyl ester; microdialysis). Appropriate controls were performed to verify the efficacy of the various blocks. Values are expressed as a percentage of maximal SkBF (SkBF(max); 50 mM sodium nitroprusside). At the initiation of local heating, SkBF rose to an initial peak, followed by a brief nadir, and a secondary, progressive rise to a plateau. Axon reflex block decreased the initial peak from 75+3 to 32 +/- 2% SkBF(max) (P < 0.01 vs. control) but did not affect the plateau. NOS inhibition before and throughout local heating reduced the initial peak from 75 +/- 3 to 56 +/- 3% SkBF(max) (P < 0.01) and the plateau from 87 +/- 4 to 40 +/- 5%. NOS inhibition during axon reflex block did not further reduce the initial SkBF peak compared with axon reflex block alone. Antebrachial nerve block did not affect the local heating SkBF response. The primary finding of these studies is that there are at least two independent mechanisms contributing to the rise in SkBF during nonpainful local heating: a fast-responding vasodilator system mediated by the axon reflexes and a more slowly responding vasodilator system that relies on local production of NO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.