ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Accommodation enhances depolarizing inhibition in central neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed.
- Age-related impact of phenobarbital in suppressing prenatal alcohol exposure-related seizures in developing rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- Tonotopic Specializations in Number, Size, and Reversal Potential of GABAergic Inputs Fine-Tune Temporal Coding at Avian Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Excitatory-Inhibitory Synaptic Coupling in Avian Nucleus Magnocellularis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.Frontiers in neural circuits · 2020Review
- Postsynaptic FMRP Regulates SynaptogenesisThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects.PLoS computational biology · 2016Article
- Tonotopic Optimization for Temporal Processing in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- GABAergic Synchronization in Epilepsy.Cold Spring Harbor perspectives in medicine · 2016Review
- Depolarizing GABA and developmental epilepsies.CNS neuroscience & therapeutics · 2015Review
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Slowly emerging glycinergic transmission enhances inhibition in the sound localization pathway of the avian auditory system.Journal of neurophysiology · 2014Article
- The natural history of sound localization in mammals--a story of neuronal inhibition.Frontiers in neural circuits · 2014Article
- Glycinergic transmission modulates GABAergic inhibition in the avian auditory pathway.Frontiers in neural circuits · 2014Article
- Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.Frontiers in neural circuits · 2014Article
- Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Two GABAA responses with distinct kinetics in a sound localization circuit.The Journal of physiology · 2012Article
- Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.Neuroscience research · 2012Article
- Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones.The Journal of physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Neurons in the avian cochlear nucleus are depolarized by GABAergic synaptic input. We recorded GABAergic synaptic currents using the gramicidin-perforated-patch method and found their reversal potential (V(rev)) to be depolarized relative to spike threshold, which is surprising given that these inputs are inhibitory. Depolarizing IPSPs (dIPSPs) are kept below spike generation threshold by the activation of a dendrotoxin-I-sensitive, voltage-gated K(+) conductance. We show experimentally that the polarity of IPSPs contributes to their efficacy; dIPSPs induce accommodation, the positive shift in spike threshold, and are therefore more strongly inhibitory than conventional, hyperpolarizing IPSPs in the same neurons. A similar inhibitory mechanism has been described in invertebrate sensory fibers and axons of dorsal root ganglion cells and may be a general means of amplifying the strength of inhibition in cases where the size of excitatory conductances greatly exceeds that of inhibitory conductances.
Indexed as
Identifiers
11567073PMC6762906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.