ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Expression of Period genes: rhythmic and nonrhythmic compartments of the suprachiasmatic nucleus pacemaker.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 222 citations in OpenAlex.
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- A subclass of evening cells promotes the switch from arousal to sleep at dusk.Current biology : CB · 2024Article
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Time of day differences in the regulation of glutathione levels in the rat lens.Frontiers in ophthalmology · 2024Article
- A real-time measurement system for gene expression rhythms from deep tissues of freely moving mice under light-dark conditions.Biochemistry and biophysics reports · 2022Article
- Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression.Neurochemical research · 2022Review
- Single cell model for re-entrainment to a shifted light cycle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Long-Term Imaging Reveals a Circadian Rhythm of Intracellular Chloride in Neurons of the Suprachiasmatic Nucleus.Journal of biological rhythms · 2022Article
- Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis.Frontiers in endocrinology · 2022Article
- Weekend Light Shifts Evoke PersistentThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Excitatory Effects of GABA within the Suprachiasmatic Nucleus: Regulation of Na-K-2Cl Cotransporters (NKCCs) by Environmental Lighting Conditions.Journal of biological rhythms · 2020Article
- The Role of Purinergic Receptors in the Circadian System.International journal of molecular sciences · 2020Review
- Protein Kinases in the Photic Signaling of the Mammalian Circadian Clock.The Yale journal of biology and medicine · 2019Review
- Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.Nature communications · 2019Article
- Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective.Current topics in behavioral neurosciences · 2019Article
- Clinical diagnosis for dusk phenomenon of diabetes.Medicine · 2018Observational
- Functional Significance of the Excitatory Effects of GABA in the Suprachiasmatic Nucleus.Journal of biological rhythms · 2018Article
- Dimensions of wellness: Change your habits, change your life.The Canadian veterinary journal = La revue veterinaire canadienne · 2017Article
- Membrane Currents, Gene Expression, and Circadian Clocks.Cold Spring Harbor perspectives in biology · 2017Review
- The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.Frontiers in neuroendocrinology · 2017Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian circadian clock lying in the suprachiasmatic nucleus (SCN) controls daily rhythms and synchronizes the organism to its environment. In all organisms studied, circadian timekeeping is cell-autonomous, and rhythmicity is thought to be generated by a feedback loop involving clock proteins that inhibit transcription of their own genes. In the present study, we examined how these cellular properties are organized within the SCN tissue to produce rhythmicity and photic entrainment. The results show that the SCN has two compartments regulating Period genes Per1, Per2, and Per3 mRNA expression differentially. One compartment shows endogenous rhythmicity in Per1, Per2, and Per3 mRNA expression. The other compartment does not have rhythmic mRNA expression but has gated light-induced Per1 and Per2 and high levels of endogenous nonrhythmic Per3 mRNA expression. These results reveal the occurrence of differential regulation of clock genes in two distinct SCN regions and suggest a potential mechanism for producing functional differences in distinct SCN subregions.
Indexed as
Identifiers
11567064PMC3275352W2127447141What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.