ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Soluble guanylate cyclase is required during development for visual system function in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Function and regulation of nitric oxide signaling in Drosophila.Molecules and cells · 2024Review
- Nitric oxide-soluble guanylyl cyclase pathway as a contributor to age-related memory impairment in Drosophila.Aging cell · 2022Article
- Article
- Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior.PLoS genetics · 2020Article
- A review of the actions of Nitric Oxide in development and neuronal function in major invertebrate model systems.AIMS neuroscience · 2019Review
- Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance.Development (Cambridge, England) · 2014Article
- Article
- Nitric oxide synthesis and cGMP production is important for neurite growth and synapse remodeling after axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma.PloS one · 2013Article
- Article
- Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.PloS one · 2009Article
- Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling.BMC neuroscience · 2007Article
- Soluble Guanylyl Cyclases in Invertebrates: Targets for NO and O(2).Advances in experimental biology · 2007Article
- The role of cyclic nucleotides in axon guidance.Advances in experimental medicine and biology · 2007Article
- Behaviour genetics of Drosophila: non-sexual behaviour.Journal of genetics · 2005Review
- The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The Zuker collection: a resource for the analysis of autosomal gene function in Drosophila melanogaster.Genetics · 2004Article
- Invertebrates yield a plethora of atypical guanylyl cyclases.Molecular neurobiology · 2004Review
- A genetic screen for synaptic transmission mutants mapping to the right arm of chromosome 3 in Drosophila.Genetics · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A requirement for nitric oxide (NO) in visual system development has been demonstrated in many model systems, but the role of potential downstream effector molecules has not been established. Developing Drosophila photoreceptors express an NO-sensitive soluble guanylate cyclase (sGC), whereas the optic lobe targets express NO synthase. Both of these molecules are expressed after photoreceptor outgrowth to the optic lobe, when retinal growth cones are actively selecting their postsynaptic partners. We have previously shown that inhibition of the NO-cGMP pathway in vitro leads to overgrowth of retinal axons. Here we examined flies mutant for the alpha subunit gene of the Drosophila sGC (Gcalpha1). This mutation severely reduced but did not abolish GCalpha1 protein levels and NO-stimulated sGC activity in the developing photoreceptors. Although few mutant individuals possessed a disorganized retinal projection pattern, pharmacological NOS inhibition during metamorphosis increased this disorganization in mutants to a greater degree than in the wild type. Adult mutants lacked phototactic behavior, and the off-transient component of electroretinograms was frequently absent or greatly reduced in amplitude. Normal phototaxis and off-transient amplitude were restored by heat shock-mediated Gcalpha1 expression applied during metamorphosis but not in the adult. We propose that diminished sGC activity in the visual system during development causes inappropriate or inadequate formation of first-order retinal synapses, leading to defects in visual system function and visually mediated behavior.
Indexed as
Identifiers
11567060PMC6762879W1864014337What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.