ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- SDF and GABA interact to regulate axophilic migration of GnRH neurons.Journal of cell science · 2012Article
- Lipid raft segregation modulates TRPM8 channel activity.The Journal of biological chemistry · 2009Article
- Supramolecular assemblies and localized regulation of voltage-gated ion channels.Physiological reviews · 2009Review
- Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide.Neuroscience · 2007Article
- Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins.Pflugers Archiv : European journal of physiology · 2007Article
- Signal transduction pathway for the substance P-induced inhibition of rat Kir3 (GIRK) channel.The Journal of physiology · 2005Article
- A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Neurotransmitter modulation of neuronal calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1.Molecular neurobiology · 2002Review
- G protein modulation of CaV2 voltage-gated calcium channels.Channels (Austin, Tex.)Review
- Review
- Multiple serotonergic mechanisms contributing to sensitization in aplysia: evidence of diverse serotonin receptor subtypes.Learning & memory (Cold Spring Harbor, N.Y.)Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Inhibition of calcium channels by G-protein-coupled receptors depends on the nature of the Galpha subunit, although the Gbetagamma complex is thought to be responsible for channel inhibition. Ca currents in hypothalamic neurons and N-type calcium channels expressed in HEK-293 cells showed robust inhibition by G(i)/G(o)-coupled galanin receptors (GalR1), but not by Gq-coupled galanin receptors (GalR2). However, deletions in the C terminus of alpha(1B-1) produced Ca channels that were inhibited after activation of both GalR1 and GalR2. Inhibition of protein kinase C (PKC) also revealed Ca current modulation by GalR2. Imaging studies using green fluorescent protein fusions of the C terminus of alpha(1B) demonstrated that activation of the GalR2 receptor caused translocation of the C terminus of alpha(1B-1) to the membrane and co-localization with Galphaq and PKC. Similar translocation was not seen with a C-terminal truncated splice variant, alpha(1B-2). Immunoprecipitation experiments demonstrated that Galphaq interacts directly with the C terminus of the alpha(1B) subunit. These results are consistent with a model in which local activation of PKC by channel-associated Galphaq blocks modulation of the channel by Gbetagamma released by Gq-coupled receptors.
Indexed as
Identifiers
11567049PMC6762920What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.