ArticleJournal of bacteriology2001
Role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
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- First Insight into the Degradome ofInternational journal of molecular sciences · 2024Article
- TMT-Based Proteomic Analysis Reveals the Molecular Mechanisms of Sodium Pheophorbide A against Black Spot Needle Blight Caused byJournal of fungi (Basel, Switzerland) · 2024Article
- Regulation of nutrient utilization in filamentous fungi.Applied microbiology and biotechnology · 2023Review
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- Metabolic Profiling-Based Evaluation of the Fermentative Behavior ofFoods (Basel, Switzerland) · 2020Article
- The Early Asexual Development RegulatorFrontiers in microbiology · 2019Article
- Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.Molecular microbiology · 2018Review
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- Nitrogen regulation of fungal secondary metabolism in fungi.Frontiers in microbiology · 2014Review
- The molecular components of the extracellular protein-degradation pathways of the ectomycorrhizal fungus Paxillus involutus.The New phytologist · 2013Article
- Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus.Toxins · 2013Article
- A sensing role of the glutamine synthetase in the nitrogen regulation network in Fusarium fujikuroi.PloS one · 2013Article
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- Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.Molecular microbiology · 2010Article
- The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci.Eukaryotic cell · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Glutamine synthetase (GS), EC 6.3.1.2, is a central enzyme in the assimilation of nitrogen and the biosynthesis of glutamine. We have isolated the Aspergillus nidulans glnA gene encoding GS and have shown that glnA encodes a highly expressed but not highly regulated mRNA. Inactivation of glnA results in an absolute glutamine requirement, indicating that GS is responsible for the synthesis of this essential amino acid. Even when supplemented with high levels of glutamine, strains lacking a functional glnA gene have an inhibited morphology, and a wide range of compounds have been shown to interfere with repair of the glutamine auxotrophy. Heterologous expression of the prokaryotic Anabaena glnA gene from the A. nidulans alcA promoter allowed full complementation of the A. nidulans glnADelta mutation. However, the A. nidulans fluG gene, which encodes a protein with similarity to prokaryotic GS, did not replace A. nidulans glnA function when similarly expressed. Our studies with the glnADelta mutant confirm that glutamine, and not GS, is the key effector of nitrogen metabolite repression. Additionally, ammonium and its immediate product glutamate may also act directly to signal nitrogen sufficiency.
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