Evidence map›Paper›PMID 11566890›Full record

ArticleThe EMBO journal2001

Distinct requirements for C.elegans TAF(II)s in early embryonic transcription.

A K Walker, J H Rothman, Y Shi, T K Blackwell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
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  7. Review
  8. Distinct modes of gene regulation by a cell-specific transcriptional activator.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  9. Article
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  11. Article
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  18. Article
  19. Isoform-specific interaction of HP1 with human TAFII130.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
  20. cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.Proceedings of the National Academy of Sciences of the United States of America · 2002
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

A K WalkerCenter for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
J H Rothman
Y Shi
T K Blackwell
Harvard University · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USUniversity of California, Santa Barbara · US

Funding

TRANSCRIPTION COFACTORS IN DIFFERENTIATIONR01GM058012 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHI, YANG · 1999 to 2011
$4.1M
BLASTOMERE AND GERM LAYER IDENTITY IN C ELEGANSR01HD037487 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ROTHMAN, JOEL H. · 1999 to 2003
$1.0M
NICHD NIH HHS HD37487NICHD NIH HHS R01 HD037487NIDDK NIH HHS F32 DK0946NIGMS NIH HHS R01 GM058012NIGMS NIH HHS R01 GM58012
6 · The paper itself

Abstract

TAF(II)s are conserved components of the TFIID, TFTC and SAGA-related mRNA transcription complexes. In yeast (y), yTAF(II)17 is required broadly for transcription, but various other TAF(II)s appear to have more specialized functions. It is important to determine how TAF(II)s contribute to transcription in metazoans, which have larger and more diverse genomes. We have examined TAF(II) functions in early Caenorhabditis elegans embryos, which can survive without transcription for several cell generations. We show that taf-10 (yTAF(II)17) and taf-11 (yTAF(II)25) are required for a significant fraction of transcription, but apparently are not needed for expression of multiple developmental and other metazoan-specific genes. In contrast, taf-5 (yTAF(II)48; human TAF(II)130) seems to be required for essentially all early embryonic mRNA transcription. We conclude that TAF-10 and TAF-11 have modular functions in metazoans, and can be bypassed at many metazoan-specific genes. The broad involvement of TAF-5 in mRNA transcription in vivo suggests a requirement for either TFIID or a TFTC-like complex.

Indexed as

Gene Expression Regulation, DevelopmentalSaccharomyces cerevisiae ProteinsTATA-Binding Protein Associated FactorsTranscription Factor TFIIDAnimalsCaenorhabditis elegansCell DifferentiationDNA-Binding ProteinsDNA Polymerase IIEmbryo, MammalianEmbryonic and Fetal DevelopmentEmbryo, NonmammalianHumansPhosphorylationPromoter Regions, GeneticRNADNA-Binding ProteinsDNA Polymerase IIRNASaccharomyces cerevisiae ProteinsTAF1 protein, S cerevisiaeTAF4 protein, humanTAF9 protein, S cerevisiaeTATA-Binding Protein Associated FactorsTranscription FactorsTranscription Factors, TFIITranscription Factor TFIID

Identifiers

PMID11566890
PMCPMC125634
OpenAlexW2011270891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.