ArticleBiophysical journal2001
Nonlinear myofilament regulatory processes affect frequency-dependent muscle fiber stiffness.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Analysis of metabolite and strain effects on cardiac cross-bridge dynamics using model linearisation techniques.Frontiers in physiology · 2023Article
- A new myofilament contraction model with ATP consumption for ventricular cell model.The journal of physiological sciences : JPS · 2018Article
- Rat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms.American journal of physiology. Heart and circulatory physiology · 2015Article
- A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges.PLoS computational biology · 2015Article
- Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation.Frontiers in physiology · 2014Article
- A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements.Frontiers in physiology · 2014Article
- The tropomyosin binding region of cardiac troponin T modulates crossbridge recruitment dynamics in rat cardiac muscle fibers.Journal of molecular biology · 2013Article
- Modeling the chemoelectromechanical behavior of skeletal muscle using the parallel open-source software library OpenCMISS.Computational and mathematical methods in medicine · 2013Article
- Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity.Journal of molecular and cellular cardiology · 2013Article
- An analysis of deformation-dependent electromechanical coupling in the mouse heart.The Journal of physiology · 2012Article
- Cardiomyopathy-Related Mutations in Cardiac Troponin C, L29Q and G159D, Have Divergent Effects on Rat Cardiac Myofiber Contractile Dynamics.Biochemistry research international · 2012Article
- Cardiac electromechanical models: from cell to organ.Frontiers in physiology · 2011Article
- The role of thin filament cooperativity in cardiac length-dependent calcium activation.Biophysical journal · 2010Article
- Myofilament length dependent activation.Journal of molecular and cellular cardiology · 2010Review
- A metabolite-sensitive, thermodynamically constrained model of cardiac cross-bridge cycling: implications for force development during ischemia.Biophysical journal · 2010Article
- A mathematical model of fatigue in skeletal muscle force contraction.Journal of muscle research and cell motility · 2007Article
- Force transients and minimum cross-bridge models in muscular contraction.Journal of muscle research and cell motility · 2007Review
- Troponin T modulates sarcomere length-dependent recruitment of cross-bridges in cardiac muscle.Biophysical journal · 2006Article
- Multi-scale computational modelling in biology and physiology.Progress in biophysics and molecular biologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the role of nonlinear myofilament regulatory processes in sarcomeric mechanodynamics, a model of myofilament kinetic processes, including thin filament on-off kinetics and crossbridge cycling kinetics with interactions within and between kinetic processes, was built to predict sarcomeric stiffness dynamics. Linear decomposition of this highly nonlinear model resulted in the identification of distinct contributions by kinetics of recruitment and by kinetics of distortion to the complex stiffness of the sarcomere. Further, it was established that nonlinear kinetic processes, such as those associated with cooperative neighbor interactions or length-dependent crossbridge attachment, contributed unique features to the stiffness spectrum through their effect on recruitment. Myofilament model-derived sarcomeric stiffness reproduces experimentally measured sarcomeric stiffness with remarkable fidelity. Consequently, characteristic features of the experimentally determined stiffness spectrum become interpretable in terms of the underlying contractile mechanisms that are responsible for specific dynamic behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.