ArticleBiophysical journal2001
Simulated refolding of stretched titin immunoglobulin domains.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Contribution of hydrophobic interactions to protein mechanical stability.Computational and structural biotechnology journal · 2022Article
- Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy.Biophysical journal · 2018Article
- Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium.European biophysics journal : EBJ · 2013Article
- Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats.The Journal of biological chemistry · 2012Article
- Mechanical anisotropy of ankyrin repeats.Biophysical journal · 2012Article
- Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations.The Journal of biological chemistry · 2010Article
- An improved strategy for generating forces in steered molecular dynamics: the mechanical unfolding of titin, e2lip3 and ubiquitin.PloS one · 2010Article
- Interplay of mechanical and binding properties of Fibronectin type I.Theoretical chemistry accounts · 2010Article
- Equilibrium sampling for biomolecules under mechanical tension.Biophysical journal · 2010Article
- Discovery through the computational microscope.Structure (London, England : 1993) · 2009Review
- Mechanochemistry: one bond at a time.ACS nano · 2009Article
- Tensile mechanics of alanine-based helical polypeptide: force spectroscopy versus computer simulations.Biophysical journal · 2009Article
- Pulling single molecules of titin by AFM--recent advances and physiological implications.Pflugers Archiv : European journal of physiology · 2008Review
- Secondary and tertiary structure elasticity of titin Z1Z2 and a titin chain model.Biophysical journal · 2007Article
- Mechanism of titin unfolding by force: insight from quasi-equilibrium molecular dynamics calculations.Biophysical journal · 2006Article
- Force spectroscopy of single multidomain biopolymers: a master equation approach.The European physical journal. E, Soft matter · 2005Article
- Poly-Ig tandems from I-band titin share extended domain arrangements irrespective of the distinct features of their modular constituents.Journal of muscle research and cell motility · 2005Article
- Origin of mechanical strength of bovine carbonic anhydrase studied by molecular dynamics simulation.Biophysical journal · 2004Article
- Steered molecular dynamics studies of titin I1 domain unfolding.Biophysical journal · 2002Article
- Unfolding of titin domains studied by molecular dynamics simulations.Journal of muscle research and cell motility · 2002Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Steered molecular dynamics (SMD) is used to investigate forced unfolding and spontaneous refolding of immunoglobulin I27, a domain of the muscle protein titin. Previous SMD simulations revealed the events leading to stretch-induced unfolding of I27, the rupture of hydrogen bonds bridging beta-strands A and B, and those bridging beta-strands A' and G, the latter rupture occurring at an extension of approximately 15 A and preceding the complete unfolding. Simulations are now used to study the refolding of partially unfolded I27 domains. The results reveal that stretched domains with ruptured interstrand hydrogen bonds shrink along the extension direction. Two types of refolding patterns are recognized: for separated beta-strands A' and G, in most simulations five of the six hydrogen bonds between A' and G stably reformed in 2 ns, whereas for separated beta-strands A and B hydrogen bonds seldom reformed in eight 2-ns simulations. The mechanical stability of the partially refolded intermediates has been tested by re-stretching.
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