ArticleBiophysical journal2001
Spatial range of autocrine signaling: modeling and computational analysis.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- LDAcoop: Integrating non-linear population dynamics into the analysis of clonogenic growth in vitro.Molecular oncology · 2026Article
- Spatially structured inflammatory response in the presence of a uniform stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Beyond the membrane: rethinking EGFR signaling in physiology and cancer.Cellular and molecular life sciences : CMLS · 2026Review
- Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells.Cell reports · 2024Article
- Modelling the dynamics of senescence spread.Aging cell · 2023Article
- Macroscopic quorum sensing sustains differentiating embryonic stem cells.Nature chemical biology · 2023Article
- Engineered Tissue Models to Replicate Dynamic Interactions within the Hematopoietic Stem Cell Niche.Advanced healthcare materials · 2022Review
- Clustering of catalytic nanocompartments for enhancing an extracellular non-native cascade reaction.Chemical science · 2021Article
- Encapsulation of murine hematopoietic stem and progenitor cells in a thiol-crosslinked maleimide-functionalized gelatin hydrogel.Acta biomaterialia · 2021Article
- Article
- Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain.Cellular and molecular bioengineering · 2021Article
- Modeling cell-cell communication for immune systems across space and time.Current opinion in systems biology · 2019Review
- Cytokine-mediated communication: a quantitative appraisal of immune complexity.Nature reviews. Immunology · 2019Review
- Soluble VEGFR1 signaling guides vascular patterns into dense branching morphologies.Journal of theoretical biology · 2018Article
- A systems perspective of heterocellular signaling.Essays in biochemistry · 2018Review
- Article
- Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations.PloS one · 2018Article
- Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.Nature communications · 2014Article
- Autocrine FGF feedback can establish distinct states of Nanog expression in pluripotent stem cells: a computational analysis.BMC systems biology · 2014Article
- Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms.Journal of mathematical biology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Autocrine loops formed by growth factors and their receptors have been identified in a large number of developmental, physiological, and pathological contexts. In general, the spatially distributed and recursive nature of autocrine signaling systems makes their experimental analysis, and often even their detection, very difficult. Here, we combine Brownian motion theory, Monte Carlo simulations, and reaction-diffusion models to analyze the spatial operation of autocrine loops. Within this modeling framework, the ability of autocrine cells to recapture the endogenous ligand and the distances traveled by autocrine ligands are explicitly related to ligand diffusion coefficients, density of surface receptors, ligand secretion rate, and rate constants of ligand binding and endocytic internalization. Applying our models to study autocrine loops in the epidermal growth factor receptor system, we find that autocrine loops can be highly localized--even at the level of a single cell. We demonstrate how the variations in molecular and cellular parameters may "tune" the spatial range of autocrine signals over several orders of magnitude: from microns to millimeters. We argue that this versatile regulation of the spatial range of autocrine signaling enables autocrine cells to perceive a broad spectrum of environmental information.
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Registered trials
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