ArticleNeurochemical research2001
Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation.
Article in Neurochemical research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Recombinant Uncarboxylated OsteocalcinFrontiers in endocrinology · 2017Article
- Bupivacaine crystal deposits after long-term epidural infusion.Der Anaesthesist · 2013Article
- [Development of a soft tissue ulcer after long-term peridural infusion].Der Anaesthesist · 2009Article
- [Myotoxicity of local anaesthetics: experimental myth or clinical truth?].Der Anaesthesist · 2007Review
- [Medically induced myopathia].Der Nervenarzt · 2006Review
- Hydroxyl radical formation in skeletal muscle of rats with glucocorticoid-induced myopathy.Neurochemical research · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle. A single administration of dimethyl sulphoxide, a free radical scavenger, significantly lowered concentrations of 2,5- and 2,3-dihydroxybenzoic acid. These results suggest that dimethyl sulphoxide is an effective hydroxyl radical scavenger and may be useful in the treatment of myopathy.
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Registered trials
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