ArticleMolecular and cellular biology2001
Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 69 citations in OpenAlex.
- Genetic legacy and recent cross of two ancient lineages underlie the rebound of the world's rarest primate.Science advances · 2026Article
- Gustavson syndrome is caused by an in-frame deletion in RBMX associated with potentially disturbed SH3 domain interactions.European journal of human genetics : EJHG · 2024Article
- Keratins and the plakin family cytolinker proteins control the length of epithelial microridge protrusions.eLife · 2020Article
- The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.Molecular cancer · 2015Article
- Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.eLife · 2014Article
- Plakins, a versatile family of cytolinkers: roles in skin integrity and in human diseases.The Journal of investigative dermatology · 2014Review
- Epidermal barriers.Cold Spring Harbor perspectives in medicine · 2014Review
- Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.Developmental cell · 2012Article
- Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.Nature reviews. Molecular cell biology · 2011Review
- Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.The American journal of pathology · 2011Article
- The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium.International review of cell and molecular biology · 2011Review
- Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus.Gastroenterology · 2010Article
- KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules.Journal of cell science · 2009Article
- Functions of the intermediate filament cytoskeleton in the eye lens.The Journal of clinical investigation · 2009Review
- A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis.PLoS genetics · 2008Article
- Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.The Journal of cell biology · 2007Article
- Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.The Journal of cell biology · 2006Article
- Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia.Molecular and cellular biology · 2006Article
- Differential recognition of response elements determines target gene specificity for p53 and p63.Molecular and cellular biology · 2005Article
- Periplakin gene targeting reveals a constituent of the cornified cell envelope dispensable for normal mouse development.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Envoplakin, a member of the plakin family of cytoskeletal linker proteins, is localized in desmosomes of stratified epithelial cells and is a component of the epidermal cornified envelope. Gene targeting in mouse embryonic stem cells was used to generate a null allele of envoplakin. No envoplakin transcripts from the targeted allele could be detected in the skin of newborn mice. Mice homozygous for the targeted allele were born in the normal Mendelian ratio and were fertile. They did not develop any discernible pathological phenotype up to the age of 1 year. The ultrastructural appearance of cornified envelopes from adult epidermis was indistinguishable between wild-type and knockout mice, and there was no evidence that the absence of envoplakin affected the subcellular distribution of periplakin or desmoplakin, two other plakins found in desmosomes. The proportion of immature cornified envelopes in the epidermis of newborn mice was greater in envoplakin-null animals than in heterozygous littermates or wild-type mice, and the envelopes had a larger surface area. This correlated with a slight delay in barrier acquisition during embryonic development. We conclude that although envoplakin is part of the scaffolding on which the cornified envelope is assembled, it is not essential for envelope formation or epidermal barrier function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.