ArticleMolecular and cellular biology2001
cis Recognition elements in plant mitochondrion RNA editing.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 109 citations in OpenAlex.
- Conservation of the moss RNA editing factor PPR78 despite the loss of its known cytidine-to-uridine editing sites is explained by a hidden extra target.The Plant cell · 2024Article
- Beyond a PPR-RNA recognition code: Many aspects matter for the multi-targeting properties of RNA editing factor PPR56.PLoS genetics · 2023Article
- Emergence of Novel RNA-Editing Sites by Changes in the Binding Affinity of a Conserved PPR Protein.Molecular biology and evolution · 2022Article
- GRP23 plays a core role in E-type editosomes via interacting with MORFs and atypical PPR-DYWs inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- U-to-C RNA editing by synthetic PPR-DYW proteins in bacteria and human culture cells.Communications biology · 2022Article
- RNA Editing and Its Roles in Plant Organelles.Frontiers in genetics · 2021Review
- Molecular and Functional Diversity of RNA Editing in Plant Mitochondria.Molecular biotechnology · 2018Review
- Towards a comprehensive picture of C-to-U RNA editing sites in angiosperm mitochondria.Plant molecular biology · 2018Article
- Functional divergence and origin of the DAG-like gene family in plants.Scientific reports · 2017Article
- Article
- MEF10 is required for RNA editing at nad2-842 in mitochondria of Arabidopsis thaliana and interacts with MORF8.Plant molecular biology · 2013Article
- The longest mitochondrial RNA editing PPR protein MEF12 in Arabidopsis thaliana requires the full-length E domain.RNA biology · 2013Article
- Article
- Two related RNA-editing proteins target the same sites in mitochondria of Arabidopsis thaliana.The Journal of biological chemistry · 2012Article
- Multiple organellar RNA editing factor (MORF) family proteins are required for RNA editing in mitochondria and plastids of plants.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A protein shuttle system to target RNA into mitochondria.Nucleic acids research · 2011Article
- The pentatricopeptide repeat protein OTP87 is essential for RNA editing of nad7 and atp1 transcripts in Arabidopsis mitochondria.The Journal of biological chemistry · 2011Article
- The RNA editing pattern of cox2 mRNA is affected by point mutations in plant mitochondria.PloS one · 2011Article
- Intron RNA editing is essential for splicing in plant mitochondria.Nucleic acids research · 2010Article
- Reverse genetic screening identifies five E-class PPR proteins involved in RNA editing in mitochondria of Arabidopsis thaliana.The Journal of biological chemistry · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA editing in higher plant mitochondria modifies mRNA sequences by means of C-to-U conversions at highly specific sites. To determine the cis elements involved in recognition of an editing site in plant mitochondria, deletion and site-directed mutation constructs containing the cognate cox II mitochondrial gene were introduced into purified mitochondria by electroporation. The RNA editing status was analyzed for precursor and spliced transcripts from the test construct. We found that only a restricted number of nucleotides in the vicinity of the target C residue were necessary for recognition by the editing machinery and that the nearest neighbor 3' residues were crucial for the editing process. We provide evidence that two functionally distinguishable sequences can be defined: the 16-nucleotide 5' region, which can be replaced with the same region from another editing site, and a 6-nucleotide 3' region specific to the editing site. The latter region may play a role in positioning the actual editing residue.
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