ArticleBritish journal of pharmacology2001
Neuronal nitric oxide synthase (NOS) regulates leukocyte-endothelial cell interactions in endothelial NOS deficient mice.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Biopterin metabolism and nitric oxide recoupling in cancer.Frontiers in oncology · 2023Review
- The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.Journal of neuroinflammation · 2021Article
- Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury.Frontiers in immunology · 2021Review
- Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.Mediators of inflammation · 2015Review
- Monocytes are recruited from venules during arteriogenesis in the murine spinotrapezius ligation model.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Nitric oxide synthase promotes distension-induced tracheal venular leukocyte adherence.PloS one · 2014Article
- Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry.The Journal of rheumatology · 2013Article
- Inhibition of nitric oxide synthesis enhances leukocyte rolling and adhesion in human microvasculature.Journal of inflammation (London, England) · 2012Article
- eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice.PloS one · 2012Article
- Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.The Journal of clinical investigation · 2011Article
- Diabetic eNOS-knockout mice develop accelerated retinopathy.Investigative ophthalmology & visual science · 2010Article
- Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation.BMC immunology · 2008Article
- Characterization of the non-adrenergic/non-cholinergic response to perivascular nerve stimulation in the double-perfused mesenteric bed of the mouse.British journal of pharmacology · 2007Article
- C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Intercellular communication, NO and the biology of Chinese medicine.Cell communication and signaling : CCS · 2005Article
- Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulatory effects of iNOS on acute lung inflammatory responses in mice.The American journal of pathology · 2003Article
- The role of NOS in heart failure: lessons from murine genetic models.Heart failure reviews · 2002Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was designed to examine the possible role of neuronal nitric oxide synthase (nNOS) in regulation of leukocyte - endothelial cell interactions in the absence of endothelial nitric oxide synthase (eNOS), using intravital microscopy of the cremasteric microcirculation of eNOS(-/-) mice. 2. Baseline leukocyte rolling and adhesion revealed no differences between wild-type and eNOS(-/-) mice in either the cremasteric or intestinal microcirculations. 3. Superfusion with L-NAME (100 microM) caused a progressive and significant increase in leukocyte adhesion in both wild-type and eNOS(-/-) mice, without detecting differences between the two strains of mice. 4. Superfusion with 7-nitroindazole (100 microM), a selective inhibitor of nNOS, had no effect on leukocyte adhesion in wild-type animals. However, it increased leukocyte adhesion significantly in eNOS(-/-) mice, which was reversed by systemic L-arginine pre-administration. 5. Stimulation of the microvasculature with H(2)O(2) (100 microM) induced a transient elevation in leukocyte rolling in wild-type mice. Conversely, the effect persisted during the entire 60 min of experimental protocol in eNOS(-/-) mice either with or without 7-nitroindazole. 6. Semi-quantitative analysis by RT - PCR of the mRNA for nNOS levels in eNOS(-/-) and wild-type animals, showed increased expression of nNOS in both brain and skeletal muscle of eNOS(-/-) mice. 7. In conclusion, we have demonstrated that leukocyte-endothelial cell interactions are predominantly modulated by eNOS isoform in postcapillary venules of normal mice, whereas nNOS appears to assume the same role in eNOS(-/-) mice. Interestingly, unlike eNOS there was insufficient NO produced by nNOS to overcome leukocyte recruitment elicited by oxidative stress, suggesting that nNOS cannot completely compensate for eNOS.
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