ArticleEnvironmental health perspectives2001
The immature mouse is a suitable model for detection of estrogenicity in the uterotropic bioassay.
Article in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
- Uterotropic response to the antidepressant fluoxetine (Prozac) is dependent on a functional serotonin transporter and circulating serotonin.Scientific reports · 2025Article
- Parabens effects on female reproductive health - Review of evidence from epidemiological and rodent-based studies.Reproductive toxicology (Elmsford, N.Y.) · 2024Review
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- Analysis of individual and combined estrogenic effects of bisphenol, nonylphenol and diethylstilbestrol in immature rats with mathematical models.Environmental health and preventive medicine · 2019Article
- Effects of Huang Bai (Chinese medicine · 2018Article
- Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat.Journal of toxicology and environmental health. Part A · 2017Article
- Article
- Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Metals and breast cancer.Journal of mammary gland biology and neoplasia · 2013Review
- Assessment and molecular actions of endocrine-disrupting chemicals that interfere with estrogen receptor pathways.International journal of endocrinology · 2013Article
- Low doses of 17β-estradiol rapidly improve learning and increase hippocampal dendritic spines.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Uterotrophic effects of cow milk in immature ovariectomized Sprague-Dawley rats.Environmental health and preventive medicine · 2010Article
- Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats.The Journal of nutrition · 2009Article
- Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program.BMC medical genomics · 2009Article
- Drinking water with uranium below the U.S. EPA water standard causes estrogen receptor-dependent responses in female mice.Environmental health perspectives · 2007Article
- Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague-Dawley rats.Environmental health perspectives · 2007Article
- Perinatal bisphenol A exposure increases estrogen sensitivity of the mammary gland in diverse mouse strains.Environmental health perspectives · 2007Article
- Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice.Environmental health perspectives · 2003Article
- Effects of environmentally-relevant levels of perfluorooctane sulfonate on clinical parameters and immunological functions in B6C3F1 mice.Journal of immunotoxicologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The traditional rodent uterotropic response assay has been incorporated into the U.S. Environmental Protection Agency's screening and testing program for environmental endocrine-disrupting chemicals (EDCs). While much effort continues to focus on determining protocol variables, few studies compare uterotropic responses in rats, a species commonly used in toxicologic testing, with other rodent species. In this study, we compared uterine responses in immature outbred CD-1 mice and Sprague-Dawley rats. After three daily subcutaneous injections with 17beta-estradiol (0.1-500 microg/kg/day), immature mice and rats demonstrated a similar dose-response increase in absolute uterine wet weight and uterine weight:body weight ratio. Further, morphologic and biochemical parameters of estrogenicity, including uterine epithelial cell height and number, gland number, and induction of estrogen-responsive proteins lactoferrin and complement C3, mirror wet weight increases. We conclude that mice are as well suited as rats for the uterotropic bioassay. Because of the advantages of using mice, including lower costs, less space required, and smaller amounts of compound needed for tests, mice should be given appropriate consideration in testing paradigms for EDCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.