ReviewCurrent rheumatology reports2001
Pathogenesis of reactive arthritis.
Review in Current rheumatology reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- YouTube as a source of information on reactive arthritis: a quality analysis.Zeitschrift fur Rheumatologie · 2024Article
- Immunologic derangement caused by intestinal dysbiosis and stress is the intrinsic basis of reactive arthritis.Zeitschrift fur Rheumatologie · 2024Review
- Treatment of Reactive Arthritis with Biological Agents.Current rheumatology reports · 2024Review
- Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet's disease, and iBCG-induced ReA.Rheumatology international · 2021Review
- Microbes, helminths, and rheumatic diseases.Best practice & research. Clinical rheumatology · 2020Review
- Treatment of reactive arthritis with biological agents: a review.Bioscience reports · 2020Review
- Chronic Gastrointestinal and Joint-Related Sequelae Associated with Common Foodborne Illnesses: A Scoping Review.Foodborne pathogens and disease · 2020Article
- Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis.The Journal of steroid biochemistry and molecular biology · 2019Article
- A rare cause of oligoarthritis with septic presentation.BMJ case reports · 2018Article
- HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- The Case of Reactive Arthritis Secondary toCase reports in rheumatology · 2017Article
- A case of reactive arthritis due to Clostridium difficile colitis.Journal of community hospital internal medicine perspectives · 2016Article
- The molecular basis for disease phenotype in chronic Chlamydia-induced arthritis.International journal of clinical rheumatology · 2012Article
- Reactive arthritis: developments and challenges in diagnosis and treatment.Current rheumatology reports · 2012Review
- Chlamydia-induced ReA: immune imbalances and persistent pathogens.Nature reviews. Rheumatology · 2011Article
- Th-17 associated cytokines in patients with reactive arthritis/undifferentiated spondyloarthropathy.Clinical rheumatology · 2011Article
- Patients with Chlamydia-associated arthritis have ocular (trachoma), not genital, serovars of C. trachomatis in synovial tissue.Microbial pathogenesis · 2010Article
- Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtype.The Journal of experimental medicine · 2004Review
- Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27.Gut microbesArticle
- Role of CD8(+)T cells in the host response to Chlamydia.Microbes and infectionReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is good evidence that bacteria persist in vivo in patients with reactive arthritis (ReA). While Chlamydia seem to hide inside the joint, other areas such as gut mucosa or lymph nodes seem to be more likely places for Salmonella and Yersinia. T-helper (Th) 1 cells secreting cytokines such as IFN gamma and TNF alpha are crucial for an effective elimination of these bacteria. An inhibited Th1-response could be demonstrated in ReA, probably contributing to bacterial persistence. While HLA-B27 is found in only approximately 50% of patients with acute ReA, HLA-B27 seems to be crucial for the development of features typical with chronic spondyloarthropathy, such as sacroiliitis. Among several hypotheses to explain the interaction of bacteria with HLA-B27, the most likely seems to be that until now unknown bacterial or self- antigens were presented by HLA-B27 to CD8(+) T-cells. An important site where the immunopathology takes place seems to be at the insertion of tendons and ligaments at bone. Because antibiotics have failed so far in the treatment of ReA immunomodulatory therapies, based on a better understanding of the pathogenesis, alone or in combination with antibiotics might be an option for the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.