ArticleThe Biochemical journal2001
Lipid modification of the Cu,Zn superoxide dismutase from Mycobacterium tuberculosis.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Old dogs, new tricks: New insights into the iron/manganese superoxide dismutase family.Journal of inorganic biochemistry · 2022Article
- Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM.The Journal of membrane biology · 2021Review
- Chemical Warfare at the Microorganismal Level: A Closer Look at the Superoxide Dismutase Enzymes of Pathogens.ACS infectious diseases · 2018Review
- Virulence factors of the Mycobacterium tuberculosis complex.Virulence · 2013Review
- Immobilized transition metal ions stimulate contact activation and drive factor XII-mediated coagulation.Journal of thrombosis and haemostasis : JTH · 2012Article
- Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis.PloS one · 2012Article
- Lipoproteins of bacterial pathogens.Infection and immunity · 2011Review
- Article
- N-Terminal clustering of the O-glycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC.Glycobiology · 2009Article
- Regulatory and structural properties differentiating the chromosomal and the bacteriophage-associated Escherichia coli O157:H7 Cu, Zn superoxide dismutases.BMC microbiology · 2008Article
- Transcriptional characterization of the antioxidant response of Mycobacterium tuberculosis in vivo and during adaptation to hypoxia in vitro.Tuberculosis (Edinburgh, Scotland) · 2008Article
- Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.Journal of molecular biology · 2007Article
- Interaction between leukotoxin and Cu,Zn superoxide dismutase in Aggregatibacter actinomycetemcomitans.Infection and immunity · 2007Article
- Structural properties of periplasmic SodCI that correlate with virulence in Salmonella enterica serovar Typhimurium.Journal of bacteriology · 2007Article
- Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia.Infection and immunity · 2007Article
- LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.The EMBO journal · 2006Article
- Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages.Infection and immunity · 2003Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The leader sequence of Mycobacterium tuberculosis Cu,Zn superoxide dismutase (Cu,ZnSOD) contains a prokaryotic membrane lipoprotein attachment site. In the present study, we have found that the protein, which exhibits detectable SOD activity, is lipid-modified and associated with the bacterial membrane when expressed either in M. tuberculosis or in Escherichia coli. These results provide the first demonstration of lipid modification of a Cu,ZnSOD. An analysis of the sodC genes present in available databases indicates that the same signal for lipid modification is also present in the sodC gene products from other mycobacteria and Gram-positive bacteria and, uniquely, in two distinct sodC gene products from the Gram-negative bacterium Salmonella typhimurium. Evidence is also provided for an up-regulation of M. tuberculosis sodC in response to phagocytosis by human macrophages, suggesting that Cu,ZnSOD is involved in the mechanisms that facilitate mycobacterial intracellular growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.