ArticleProceedings of the National Academy of Sciences of the United States of America2001
An unsuspected autoregulatory pathway involving apocytochrome TorC and sensor TorS in Escherichia coli.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Purification and Electron Transfer from Soluble c-Type Cytochrome TorC to TorA for Trimethylamine N-Oxide Reduction.International journal of molecular sciences · 2024Article
- Iron limitation indirectly reduces theMicrobiology spectrum · 2024Article
- Bacterial approaches to sensing and responding to respiration and respiration metabolites.Molecular microbiology · 2021Review
- A bacterial signaling system regulates noise to enable bet hedging.Current genetics · 2019Review
- Article
- Two-component signaling circuit structure and properties.Current opinion in microbiology · 2010Review
- Stimulus perception in bacterial signal-transducing histidine kinases.Microbiology and molecular biology reviews : MMBR · 2006Review
- The signaling helix: a common functional theme in diverse signaling proteins.Biology direct · 2006Article
- Genes regulated by TorR, the trimethylamine oxide response regulator of Shewanella oneidensis.Journal of bacteriology · 2004Article
- TorI, a response regulator inhibitor of phage origin in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Effects of ISSo2 insertions in structural and regulatory genes of the trimethylamine oxide reductase of Shewanella oneidensis.Journal of bacteriology · 2003Article
- Genome Reduction inmSystemsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trimethylamine N-oxide (TMAO) respiration is carried out mainly by the Tor system in Escherichia coli. This system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. Expression of the tor operon is positively controlled by the TorS/TorR phosphorelay system in response to TMAO availability and negatively regulated by apocytochrome TorC. Interaction studies showed that, when immature, TorC can no longer bind TorA efficiently but can bind the periplasmic detector region of sensor TorS. ApoTorC negative autoregulation and TMAO induction are thus mediated by the same sensor protein. As apocytochromes related to TorC could not down-regulate the tor operon, we concluded that this negative control is highly specific. Moreover, the N-terminal half of apoTorC played no role in this control but the immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region. This sophisticated autoregulatory pathway thus involves the C-terminal domain of apoTorC and allows optimal TorC biogenesis by preventing from saturation the c-type cytochrome maturation machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.