ArticleGenetics2001
Selection intensity against deleterious mutations in RNA secondary structures and rate of compensatory nucleotide substitutions.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Quantifying the Evolution of SNPs That Affect RNA Secondary Structure in Arabidopsis thaliana Genes.Molecular biology and evolution · 2025Article
- Epistasis-Driven Evolution of the SARS-CoV-2 Secondary Structure.Journal of molecular evolution · 2022Article
- Reversion is most likely under high mutation supply when compensatory mutations do not fully restore fitness costs.G3 (Bethesda, Md.) · 2022Article
- Phylogenies of the 16S rRNA gene and its hypervariable regions lack concordance with core genome phylogenies.Microbiome · 2022Article
- SSS-test: a novel test for detecting positive selection on RNA secondary structure.BMC bioinformatics · 2019Article
- Evaluation of global HIV/SIV envelope gp120 RNA structure and evolution within and among infected hosts.Virus evolution · 2018Article
- Article
- Strong epistatic selection on the RNA secondary structure of HIV.PLoS pathogens · 2014Article
- Fine-mapping and selective sweep analysis of QTL for cold tolerance in Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- Differential strengths of positive selection revealed by hitchhiking effects at small physical scales in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- A phylogenetic model for the detection of epistatic interactions.Molecular biology and evolution · 2013Article
- Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity.Nucleic acids research · 2013Review
- The dynamics of alternative pathways to compensatory substitution.BMC bioinformatics · 2013Article
- Two types of cis-trans compensation in the evolution of transcriptional regulation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The role of the effective population size in compensatory evolution.Genome biology and evolution · 2011Article
- What role does natural selection play in speciation?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The rate of establishment of complex adaptations.Molecular biology and evolution · 2010Article
- The population genetics of mutations: good, bad and indifferent.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Article
- Comparative genomics of Drosophila mtDNA: Novel features of conservation and change across functional domains and lineages.Journal of molecular evolution · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A two-locus model of reversible mutations with compensatory fitness interactions is presented; single mutations are assumed to be deleterious but neutral in appropriate combinations. The expectation of the time of compensatory nucleotide substitutions is calculated analytically for the case of tight linkage between sites. It is shown that selection increases the substitution time dramatically when selection intensity Ns > 1, where N is the diploid population size and s the selection coefficient. Computer simulations demonstrate that recombination increases the substitution time, but the effect of recombination is small when selection is weak. The amount of linkage disequilibrium generated in the process of compensatory substitution is also investigated. It is shown that significant linkage disequilibrium is expected to be rare in natural populations. The model is applied to the mRNA secondary structure of the bicoid 3' untranslated region of Drosophila. It is concluded that average selection intensity Ns against single deleterious mutations is not likely to be much larger than 1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.