ArticleGenetics2001
The functional impact of Pgm amino acid polymorphism on glycogen content in Drosophila melanogaster.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Moderate nutritional stress reprogrammes insulin responses to drive enhanced starvation tolerance in Drosophila melanogaster.The Journal of experimental biology · 2026Article
- Balanced Polymorphism at theGenes · 2022Article
- Genetic Variation for Ontogenetic Shifts in Metabolism Underlies Physiological Homeostasis inGenetics · 2019Article
- Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster.Molecular ecology · 2018Article
- Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors.BMC genomics · 2018Article
- Pleiotropic effects of a mitochondrial-nuclear incompatibility depend upon the accelerating effect of temperature in Drosophila.Genetics · 2013Article
- A genetic polymorphism evolving in parallel in two cell compartments and in two clades.BMC evolutionary biology · 2013Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution.Methods in molecular biology (Clifton, N.J.) · 2011Review
- The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Emergence of complex haplotypes from microevolutionary variation in sequence and structure of Colias phosphoglucose isomerase.Journal of molecular evolution · 2009Article
- From DNA to fitness differences: sequences and structures of adaptive variants of Colias phosphoglucose isomerase (PGI).Molecular biology and evolution · 2006Article
- Thermal selection of PGM allozymes in newly founded populations of the thermotolerant vent polychaete Alvinella pompejana.Proceedings. Biological sciences · 2004Article
- Increased expression of H11 kinase stimulates glycogen synthesis in the heart.Molecular and cellular biochemistry · 2004Article
- Latitudinal clines in Drosophila melanogaster: body size, allozyme frequencies, inversion frequencies, and the insulin-signalling pathway.Journal of genetics · 2003Article
- Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila.Genetics · 2003Article
- Doxycycline-induced expression of sense and inverted-repeat constructs modulates phosphogluconate mutase (Pgm) gene expression in adult Drosophila melanogaster.Genome biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Earlier studies of the common PGM allozymes in Drosophila melanogaster reported no in vitro activity differences. However, our study of nucleotide variation observed that PGM allozymes are a heterogeneous mixture of amino acid polymorphisms. In this study, we analyze 10 PGM protein haplotypes with respect to PGM activity, thermostability, and adult glycogen content. We find a twofold difference in activity among PGM protein haplotypes that is associated with a threefold difference in glycogen content. The latitudinal clines for several Pgm amino acid polymorphisms show that high PGM activity, and apparently higher flux to glycogen synthesis, parallel the low activity clines at G6PD for reduced pentose shunt flux in northern latitudes. This suggests that amino acid polymorphism is under selection at this branch point and may be favored for increased metabolic storage associated with stress resistance and adaptation to temperate regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.