ArticleGenetics2001
Drosophila immunity: genes on the third chromosome required for the response to bacterial infection.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effector specificity and function in Drosophila innate immunity: Getting AMPed and dropping Boms.PLoS pathogens · 2020Review
- Effects of the isoflavone prunetin on gut health and stress response in male Drosophila melanogaster.Redox biology · 2016Article
- Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility.PloS one · 2016Article
- Quantitative measurement of the immune response and sleep in Drosophila.Journal of visualized experiments : JoVE · 2012Article
- Transcriptome analyses of Bactericera cockerelli adults in response to "Candidatus Liberibacter solanacearum" infection.Molecular genetics and genomics : MGG · 2012Article
- Use of a Drosophila model to identify genes regulating Plasmodium growth in the mosquito.Genetics · 2008Article
- Dissecting innate immunity by germline mutagenesis.Immunology · 2008Review
- Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection.Genetics · 2008Article
- Microarray analyses reveal distinct roles for Rel proteins in the Drosophila immune response.Developmental and comparative immunology · 2008Article
- Drosophila eiger mutants are sensitive to extracellular pathogens.PLoS pathogens · 2007Article
- Biography of Kathryn V. Anderson.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.The Journal of cell biology · 2004Article
- Article
- Maternal control of the Drosophila dorsal-ventral body axis.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have screened the third chromosome of Drosophila melanogaster for mutations that prevent the normal immune response. We identified mutant lines on the basis of their failure to induce transcription of an antibacterial peptide gene in response to infection or their failure to form melanized clots at the site of wounding. These mutations define 14 genes [immune response deficient (ird) genes] that have distinct roles in the immune response. We have identified the molecular basis of several ird phenotypes. Two genes, scribble and kurtz/modulo, affect the cellular organization of the fat body, the tissue responsible for antimicrobial peptide production. Two ird genes encode components of the signaling pathways that mediate responses to bacterial infection, a Drosophila gene encoding a homolog of I kappa B kinase (DmIkk beta) and Relish, a Rel-family transcription factor. These genetic studies should provide a basis for a comprehensive understanding of the genetic control of immune responses in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.