ArticleGenetics2001
The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- 6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability inToxics · 2026Article
- Nuclear localization and transactivation of SYS-1/β-catenin is the result of serial gene duplications and subfunctionalizations.Cells & development · 2025Article
- Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin.Open biology · 2020Review
- RPM-1 and DLK-1 regulate pioneer axon outgrowth by controlling Wnt signaling.Development (Cambridge, England) · 2018Article
- Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β-catenin-binding interface.The Journal of biological chemistry · 2017Article
- Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development.Results and problems in cell differentiation · 2017Review
- β-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.PLoS genetics · 2015Article
- Loss-of-function of β-catenin bar-1 slows development and activates the Wnt pathway in Caenorhabditis elegans.Scientific reports · 2014Article
- Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.PloS one · 2014Article
- The evolutionary origin of epithelial cell-cell adhesion mechanisms.Current topics in membranes · 2013Article
- Cadherins and their partners in the nematode worm Caenorhabditis elegans.Progress in molecular biology and translational science · 2013Review
- β-catenin-dependent Wnt signaling in C. elegans: teaching an old dog a new trick.Cold Spring Harbor perspectives in biology · 2012Review
- Parallel duplication and partial subfunctionalization of β-catenin/armadillo during insect evolution.Molecular biology and evolution · 2012Article
- Article
- Distinct and mutually inhibitory binding by two divergent β-catenins coordinates TCF levels and activity in C. elegans.Development (Cambridge, England) · 2011Article
- The evolutionary history of the catenin gene family during metazoan evolution.BMC evolutionary biology · 2011Article
- The molecular evolution of the p120-catenin subfamily and its functional associations.PloS one · 2010Article
- kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells.Cell cycle (Georgetown, Tex.) · 2010Article
- Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta-Catenins function both in cell adhesion as part of the cadherin/catenin complex and in Wnt signal transduction as transcription factors. Vertebrates express two related proteins, beta-catenin and plakoglobin, while Drosophila has a single family member, Armadillo. Caenorhabditis elegans expresses three beta-catenin-related proteins, BAR-1, HMP-2, and WRM-1, which are quite diverged in sequence from each other and other beta-catenins. While BAR-1 and WRM-1 are known to act in Wnt-mediated processes, and HMP-2 acts in a complex with cadherin/alpha-catenin homologs, it is unclear whether all three proteins retain the other functions of beta-catenin. Here we show that BAR-1, like vertebrate beta-catenin, has redundant transcription activation domains in its amino- and carboxyl-terminal regions but that HMP-2 and WRM-1 also possess the ability to activate transcription. We show via yeast two-hybrid analysis that these three proteins display distinct patterns of protein interactions. Surprisingly, we find that both WRM-1 and HMP-2 can substitute for BAR-1 in C. elegans when expressed from the bar-1 promoter. Therefore, although their mutant phenotypes and protein interaction patterns strongly suggest that the functions of beta-catenin in other species have been segregated among three diverged proteins in C. elegans, these proteins still retain sufficient similarity to display functional redundancy in vivo.
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