Trial reportBritish journal of clinical pharmacology2001
Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers.
Trial report in British journal of clinical pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Can posttreatment blood inflammatory markers predict poor survival in gynecologic cancer?: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis.BMC musculoskeletal disorders · 2016Pooled it
- Preoperative cardiovascular evaluation in patients with cancer.Frontiers in cardiovascular medicine · 2026Review
- Antiplatelet Monotherapies for Long-Term Secondary Prevention Following Percutaneous Coronary Intervention.Journal of clinical medicine · 2025Review
- Impact of Nonadherence to Any Antiplatelet Therapy After PCI With Drug-Eluting Stents on Critical Outcomes.JACC. Asia · 2025Article
- Antiplatelet strategy during ad-hoc percutaneous coronary intervention in elective patients: how aggressive should we be?Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023Article
- Anticoagulation Options for Cranial Procedures: A Comparative Review of Aspirin, Plavix, and Aggrastat.Cureus · 2023Review
- Review
- Early Surgical Care of Anticoagulated Hip Fracture Patients Is Feasible-A Retrospective Chart Review of Hip Fracture Patients Treated with Hip Arthroplasty within 24 Hours.Journal of clinical medicine · 2022Article
- Pulmonary hemorrhage in patients receiving anti-platelets- a case series and a suggested therapeutic algorithm.Respiratory medicine case reports · 2022Article
- A case report of atraumatic splenic rupture after coronary stenting and dual antiplatelet therapy: Causality or relationship?International journal of surgery case reports · 2021Article
- Kidney allograft infarction associated with transplant renal artery stenosis in a COVID-19 kidney transplant recipient.Clinical nephrology. Case studies · 2021Article
- Continuation of Dual Antiplatelet Therapy in a Patient with a Coronary Artery Stent with Dengue Hemorrhagic Fever: A Clinical Conundrum.The American journal of tropical medicine and hygiene · 2020Article
- To Pretreat or Not to Pretreat (With Oral P2Y12 Antagonists)? That is the Question.Journal of the American Heart Association · 2017Article
- Is Taking an Antiplatelet Agent a Contraindication for Early Surgery in Displaced Femur Neck Fracture?Hip & pelvis · 2015Article
- Effect of antiplatelet therapy on patients undergoing gastroenterological surgery: thromboembolic risks versus bleeding risks during its perioperative withdrawal.World journal of surgery · 2015Article
- Bridging antiplatelet therapy in patients requiring cardiac and non-cardiac surgery: from bench to bedside.Journal of cardiovascular translational research · 2014Review
- Role of Siglec-7 in apoptosis in human platelets.PloS one · 2014Article
- Thrombin based gelatin matrix and fibrin sealant mediated clot formation in the presence of clopidogrel.Thrombosis journal · 2014Article
- Is discontinuation of clopidogrel necessary for intracapsular hip fracture surgery? Analysis of 102 hemiarthroplasties.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo study the recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers.
methodsTen healthy volunteers were treated with clopidogrel (75 mg day(-1)) for 7 days. CD62P expression and PAC-1 binding were measured by flow cytometry.
resultsAdenosine diphosphate (ADP, 30 microM)-induced platelet responses were almost completely inhibited by clopidogrel. After discontinuation of the drug, platelet function gradually increased and complete recovery was seen 7 days after the last clopidogrel dose. The mean difference (95% CI) for ADP-induced PAC-1 binding (fluorescence intensity) between baseline and 7 days after the last dose was 0.01 (0.61, -0.59). Single cell analysis provides direct evidence for an irreversible mode of action of clopidogrel.
conclusionsThis is the first report to directly demonstrate irreversibility of clopidogrel action in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.