ArticleThe Journal of comparative neurology2001
Regulation of neurotrophin-induced axonal responses via Rho GTPases.
Article in The Journal of comparative neurology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 41 citations in OpenAlex.
- Building branched tissue structures: from single cell guidance to coordinated construction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Multimodal neuroprotection induced by PACAP38 in oxygen-glucose deprivation and middle cerebral artery occlusion stroke models.Journal of molecular neuroscience : MN · 2012Article
- Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus.Molecular and cellular neurosciences · 2008Article
- Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.Neurotoxicology · 2008Article
- Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Molecular determinants of the face map development in the trigeminal brainstem.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2006Review
- Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells.Cellular & molecular biology letters · 2006Article
- Differential Trk expression in explant and dissociated trigeminal ganglion cell cultures.Journal of neurobiology · 2005Article
- A chemoattractant role for NT-3 in proprioceptive axon guidance.PLoS biology · 2004Article
- Local neurotrophin effects on central trigeminal axon growth patterns.Brain research. Developmental brain research · 2004Article
- Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons.The Journal of cell biology · 2003Article
- Slit2, a branching-arborization factor for sensory axons in the Mammalian CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Nerve growth factor (NGF) and related neurotrophins induce differential axon growth patterns from embryonic sensory neurons (Lentz et al. [1999] J. Neurosci. 19:1038-1048; Ulupinar et al. [2000a] J. Comp. Neurol 425:622-630). In wholemount explant cultures of embryonic rat trigeminal ganglion and brainstem or in dissociated cell cultures of the trigeminal ganglion, exogenous supply of NGF leads to axonal elongation, whereas neurotrophin-3 (NT-3) treatment leads to short branching and arborization (Ulupinar et al. [2000a] J. Comp. Neurol. 425:622-630). Axonal responses to neurotrophins might be mediated via the Rho GTPases. To investigate this possibility, we prepared wholemount trigeminal pathway cultures from E15 rats. We infected the ganglia with recombinant vaccinia viruses that express GFP-tagged dominant negative Rac, Rho, or constitutively active Rac or treated the cultures with lysophosphatitic acid (LPA) to activate Rho. We then examined axonal responses to NGF by use of the lipophilic tracer DiI. Rac activity induced longer axonal growth from the central trigeminal tract, whereas the dominant negative construct of Rac eliminated NGF-induced axon outgrowth. Rho activity also significantly reduced, and the Rho dominant negative construct increased, axon growth from the trigeminal tract. Similar alterations in axonal responses to NT-3 and brain-derived neurotrophic factor were also noted. Our results demonstrate that Rho GTPases play a major role in neurotrophin-induced axonal differentiation of embryonic trigeminal axons.
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