ArticleJournal of virology2001
Arginine-glycine-aspartic acid motif is critical for human parechovirus 1 entry.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 82 citations in OpenAlex.
- Emergence of a New Pathogen: A Retrospective Study of HPeV-5 Central Nervous System Disease in Alberta, Canada.Viruses · 2024Article
- Review
- An Emerging Human Parechovirus Type 5 Causing Sepsis-Like Illness in Infants in Australia.Viruses · 2019Article
- A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody.Journal of virology · 2019Article
- Human Parechovirus: an Increasingly Recognized Cause of Sepsis-Like Illness in Young Infants.Clinical microbiology reviews · 2018Review
- Polarized Entry of Human Parechoviruses in the Airway Epithelium.Frontiers in cellular and infection microbiology · 2018Article
- Antifungal azoles itraconazole and posaconazole exhibit potent in vitro antiviral activity against clinical isolates of parechovirus A3 (Picornaviridae).Antiviral research · 2018Article
- Structure of deformed wing virus, a major honey bee pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Virion Structure of Iflavirus Slow Bee Paralysis Virus at 2.6-Angstrom Resolution.Journal of virology · 2016Article
- The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid.Journal of virology · 2016Article
- Human Parechovirus 1 Infection Occurs via αVβ1 Integrin.PloS one · 2016Article
- Role of Heparan Sulfate in Cellular Infection of Integrin-Binding Coxsackievirus A9 and Human Parechovirus 1 Isolates.PloS one · 2016Article
- Structural Basis of Human Parechovirus Neutralization by Human Monoclonal Antibodies.Journal of virology · 2015Article
- Human Memory B Cells Producing Potent Cross-Neutralizing Antibodies against Human Parechovirus: Implications for Prevalence, Treatment, and Diagnosis.Journal of virology · 2015Article
- Article
- Identification of a conserved B-cell epitope on duck hepatitis A type 1 virus VP1 protein.PloS one · 2015Article
- High pressure processing and its application to the challenge of virus-contaminated foods.Food and environmental virology · 2013Review
- Human parechovirus genotypes -10, -13 and -15 in Pakistani children with acute dehydrating gastroenteritis.PloS one · 2013Article
- Endocytosis of integrin-binding human picornaviruses.Advances in virology · 2012Article
- Human parechovirus infection in children hospitalized with acute gastroenteritis in Sri Lanka.Journal of clinical microbiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with integrins, and that downstream amino acids can have an influence on function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.